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Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; This study evaluates the influence of clinicopathological characteristics, bacillus Calmette-Gu\u00e9rin (BCG) therapeutic schedule [maintenance (mBCG) or induction (iBCG)], and TNF-\u03b1 and IL-4 polymorphisms on the outcome of non-muscle-invasive bladder cancer patients treated with BCG. &lt;i&gt;Material and Methods:&lt;\/i&gt; DNA was extracted from 125 bladder cancer patients treated with BCG; &lt;i&gt;TNF-308G\/A&lt;\/i&gt; and &lt;i&gt;IL4-590C\/T&lt;\/i&gt; polymorphisms were genotyped. &lt;i&gt;Results:&lt;\/i&gt; The &lt;i&gt;TNF-308&lt;\/i&gt;A allele carriers had an increased risk of developing multiple tumors (OR: 2.80, p = 0.031). However, &lt;i&gt;IL4-590&lt;\/i&gt; T carriers also had an increased risk of developing multiple and carcinoma in situ tumors (OR: 2.52, p = 0.033). For these polymorphisms, no association was found with BCG treatment outcome. When treated with iBCG, patients with multiple tumors had shorter recurrence-free survival (RFS) compared with those with a single tumor (p = 0.004); nevertheless, patients with multifocal tumors have improved RFS when treated with mBCG. &lt;i&gt;Conclusions:&lt;\/i&gt; Overall, the results suggest that multiple tumors and\/or carcinoma in situ development are associated with the &lt;i&gt;IL4-590C\/T &lt;\/i&gt;and &lt;i&gt;TNF-308G\/A&lt;\/i&gt; polymorphisms, and emphasize the effectiveness of the mBCG schedule.<\/jats:p>","DOI":"10.1159\/000331882","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T07:46:48Z","timestamp":1321861608000},"page":"457-463","source":"Crossref","is-referenced-by-count":6,"title":["IL-4 and TNF-\u03b1 Polymorphisms Are Associated with Risk of Multiple Superficial Tumors or Carcinoma in situ 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