{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:25:16Z","timestamp":1768883116408,"version":"3.49.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>We describe 5 cases of anti-tumor necrosis factor-alpha (anti-TNF-\u03b1) induced psoriasiform eruptions with severe scalp involvement inducing inflammatory alopecia and review the literature on this subject. All our 5 patients were provided topical therapy, with good results in only 1 case. The remaining 4 were provided systemic therapy (methotrexate \u00b1 cyclosporine): 3 concomitantly suspended the anti-TNF-\u03b1 treatment (2 are currently clear\/almost clear but 1 has so far only observed mild improvement) and 1 switched anti-TNF-\u03b1 (recurrent flare-ups of the disease continue). So far, no patient has developed scarring alopecia. To our knowledge, a total of 15 cases of anti-TNF-\u03b1 induced psoriatic alopecia have been described. Anti-TNF-\u03b1 was discontinued in 9 of the 15 patients and systemic therapy was provided to 9 of the 15 patients. Nonetheless, 2 patients developed scarring alopecia. We conclude that in anti-TNF-\u03b1 induced psoriasiform eruptions some patients may respond to topical treatment, however in cases of severe scalp involvement anti-TNF-\u03b1 suspension and systemic treatment should be considered in order to avoid scarring alopecia.<\/jats:p>","DOI":"10.1159\/000342503","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T09:16:59Z","timestamp":1349687819000},"page":"163-167","source":"Crossref","is-referenced-by-count":42,"title":["Anti-TNF-Alpha Induced Psoriasiform Eruptions with Severe Scalp Involvement and Alopecia: Report of Five Cases and Review of the Literature"],"prefix":"10.1159","volume":"225","author":[{"given":"F.","family":"Os\u00f3rio","sequence":"first","affiliation":[]},{"given":"F.","family":"Magro","sequence":"additional","affiliation":[]},{"given":"C.","family":"Lisboa","sequence":"additional","affiliation":[]},{"given":"S.","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"G.","family":"Macedo","sequence":"additional","affiliation":[]},{"given":"H.","family":"Bettencourt","sequence":"additional","affiliation":[]},{"given":"F.","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"S.","family":"Magina","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2012,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2011.04866.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semarthrit.2010.04.003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2007.02335.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-1470.2011.01521.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0408506102"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080%2F09546630802441234"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2165%2F00128071-200809010-00001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cgh.2010.07.022"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.2007.087288"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fibd.21643"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.gcb.2009.10.021"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:48:20Z","timestamp":1745434100000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,11,1]]},"published-print":{"date-parts":[[2012,11,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000342503","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}