{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:36:48Z","timestamp":1777635408527,"version":"3.51.4"},"reference-count":31,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T00:00:00Z","timestamp":1356652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T00:00:00Z","timestamp":1356652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> To compare biomechanical properties of vaginal tissues between women with and without pelvic organ prolapse (POP) and investigate factors that may influence these properties. <b><i>Methods:<\/i><\/b> Forty patients submitted to POP surgery and 15 non-POP cadavers were evaluated. The tissue was excised from anterior and posterior middle third vagina. The biomechanical properties considered were stiffness (E) and maximum stress (S<sub>max<\/sub>), and they were evaluated by means of uniaxial tension tests. <b><i>Results:<\/i><\/b> POP patients were associated with higher values of E (13.1 \u00b1 0.8 vs. 9.5 \u00b1 0.7 MPa; p < 0.001) and S<sub>max<\/sub> (5.3 \u00b1 0.5 vs. 3.2 \u00b1 0.9 MPa; p < 0.001) in the anterior vaginal wall compared to the posterior wall. In contrast, non-POP women presented lower values of E (6.9 \u00b1 1.1 vs. 10.5 \u00b1 1.0 MPa; p = 0.01) and S<sub>max<\/sub> (2.6 \u00b1 0.4 vs. 3.5 \u00b1 0.4 MPa; p = 0.043) in the anterior wall. The occurrence of POP was the only independent predictor of higher values of E and S<sub>max<\/sub> in anterior vaginal samples (p = 0.003 and p = 0.008, respectively). Women with severe anterior vaginal prolapse presented higher levels of E and S<sub>max<\/sub> in the anterior sample compared to those with lower POP stages (p = 0.001 and p = 0.01; respectively). <b><i>Conclusion:<\/i><\/b> Women with POP present significant changes of biomechanical properties in the vagina.<\/jats:p>","DOI":"10.1159\/000343230","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T08:00:59Z","timestamp":1356595259000},"page":"85-92","source":"Crossref","is-referenced-by-count":50,"title":["Biomechanical Properties of Vaginal Tissue in Women with Pelvic Organ Prolapse"],"prefix":"10.1159","volume":"75","author":[{"given":"Pedro","family":"Martins","sequence":"first","affiliation":[]},{"given":"Agnaldo","family":"Lopes Silva-Filho","sequence":"additional","affiliation":[]},{"given":"Andrea Moura","family":"Rodrigues Maciel da Fonseca","sequence":"additional","affiliation":[]},{"given":"Agostinho","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Liliana","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Teresa","family":"Mascarenhas","sequence":"additional","affiliation":[]},{"given":"Renato M.","family":"Natal Jorge","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio 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