{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:22:12Z","timestamp":1768638132303,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To characterize the neovascular lesions of patients with age-related macular degeneration (AMD) and outer retinal tubulations (ORTs). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A retrospective study of 377 eyes with exudative AMD, submitted to intravitreal anti-angiogenic treatment. Patients were divided into 2 groups according to the presence or absence of ORTs on spectral-domain optical coherence tomography (SD-OCT; group 1 - with ORTs; group 2 - without ORTs). Age, best corrected visual acuity (BCVA), fluorescein angiography characteristics, presence of subretinal fibrosis and subfoveal photoreceptor integrity on SD-OCT were analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Although both groups had a BCVA gain during the follow-up period, initial and final BCVA were lower in group 1 (p = 0.020 and p = 0.042, respectively). There was no statistically significant difference in the BCVA variation between the 2 groups (p = 0.907). Regarding the initial angiographic lesion type, there was a statistically significant difference between the 2 groups (p = 0.008): group 1 had more lesions with a classic component and group 2 had more occult lesions with no classic component. There was a statistically significant difference concerning the loss of subfoveal photoreceptor integrity (p = 0.0007). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Even though AMD patients with ORTs were associated with poor visual outcomes, we reported BCVA improvement. AMD patients with a classical component in their lesions are prone to develop ORTs.<\/jats:p>","DOI":"10.1159\/000346854","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T08:32:31Z","timestamp":1363077151000},"page":"147-151","source":"Crossref","is-referenced-by-count":30,"title":["Characterization of Neovascular Age-Related Macular Degeneration Patients with Outer Retinal Tubulations"],"prefix":"10.1159","volume":"229","author":[{"given":"F.","family":"Faria-Correia","sequence":"first","affiliation":[]},{"given":"R.","family":"Barros-Pereira","sequence":"additional","affiliation":[]},{"given":"L.","family":"Queir\u00f3s-Mendanha","sequence":"additional","affiliation":[]},{"given":"S.","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"L.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[]},{"given":"M.S.","family":"Falc\u00e3o","sequence":"additional","affiliation":[]},{"given":"E.","family":"Brand\u00e3o","sequence":"additional","affiliation":[]},{"given":"F.","family":"Falc\u00e3o-Reis","sequence":"additional","affiliation":[]},{"given":"A.M.","family":"Carneiro","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1103334"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.159160"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102673"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2009.211"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.01.028"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.01.024"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.363"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.11.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.326"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182247535"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.01.017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.02.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00145-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.09.042"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:50:39Z","timestamp":1745434239000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000346854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,4,1]]},"published-print":{"date-parts":[[2013,4,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000346854","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}