{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:21:29Z","timestamp":1771550489008,"version":"3.50.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> E-cadherin and \u03b2-catenin are adhesion molecules that promote integrity and stability of the urothelium. A decrease in their expression is associated with more aggressive tumour phenotypes with the ability to invade and metastasize. <b><i>Material and Methods:<\/i><\/b> 45 ICR male mice were used, of which 25 received <i>N<\/i>-butyl-<i>N<\/i>-(4-hydroxybutyl)nitrosamine (0.05%) in drinking water for a period of 12 weeks. Immunohistochemical expression was evaluated in all urinary bladder preparations for E-cadherin and for \u03b2-catenin. <b><i>Results:<\/i><\/b> Preneoplastic lesions showed staining patterns similar to normal urothelium. In simple and nodular hyperplasia, membrane staining was dominant (66.7-78.6 and 50-100%, respectively). In dysplasia a cytoplasmic pattern was prevalent (86.7-100%). Neoplastic lesions exhibit an abnormal staining pattern (100%) with heterogeneous staining (cytoplasmic, nuclear and membrane staining). A strong correlation was observed between both adhesion molecule staining patterns (r = 0.83; p = 0.039). <b><i>Conclusions:<\/i><\/b> In mice, as in humans, E-cadherin and \u03b2-catenin are valuable tools to investigate cellular adhesion status of urothelium and can be considered as indicators of tumour aggressiveness and evolution.<\/jats:p>","DOI":"10.1159\/000348329","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T13:45:10Z","timestamp":1363873510000},"page":"462-466","source":"Crossref","is-referenced-by-count":3,"title":["E-Cadherin and \u03b2-Catenin Expression during Urothelial Carcinogenesis Induced by <b><i>N<\/i><\/b>-butyl-<b><i>N<\/i><\/b>-(4-hydroxybutyl) nitrosamine in Mice"],"prefix":"10.1159","volume":"91","author":[{"given":"C.","family":"Vasconcelos-N\u00f3brega","sequence":"first","affiliation":[]},{"given":"C.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"H.","family":"Vala","sequence":"additional","affiliation":[]},{"given":"A.","family":"Cola\u00e7o","sequence":"additional","affiliation":[]},{"given":"L.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"C.","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"P.A.","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01513.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(99)01461-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00158-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00759-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2003.11.007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000322962"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.04.016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9044-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2005.08.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.12.005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-000-0783-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000151412"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000335519"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000331931"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.10.018"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.399"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65245-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(93)90028-O"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-005-0919-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00262-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1233"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2330"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/348329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:55:07Z","timestamp":1745434507000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000348329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000348329","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}