{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:12:45Z","timestamp":1772205165656,"version":"3.50.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Neurol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Cognitive and behavioral impairments are considered to occur frequently in amyotrophic lateral sclerosis\/motor neuron disease (MND). Rarely, apraxia has been reported in MND. Orofacial, or buccofacial, apraxia is characterized by a loss of voluntary control of facial, lingual, pharyngeal and masticatory muscles in the presence of preserved reflexive and automatic functions of the same muscles. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We report a patient with MND who presented with spastic dysarthria and asymmetric orofacial apraxia. She progressed to frontotemporal dementia (FTD). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Clinical and neurophysiological examinations were suggestive of bulbar-onset MND-FTD. Tractography showed a reduction of fractional anisotropy in the centrum semiovale, corona radiata, corticomedullary pathway and inferior aspect of the medulla; the changes were more severe on the left side. To our knowledge, this is the first report of an asymmetric presentation of an apraxic syndrome in MND-FTD.<\/jats:p>","DOI":"10.1159\/000349895","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T08:32:25Z","timestamp":1362645145000},"page":"47-51","source":"Crossref","is-referenced-by-count":15,"title":["Orofacial Apraxia in Motor Neuron Disease"],"prefix":"10.1159","volume":"5","author":[{"given":"Patr\u00edcia","family":"Pita Lobo","sequence":"first","affiliation":[]},{"given":"Susana","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Luz","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Reim\u00e3o","sequence":"additional","affiliation":[]},{"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10072-010-0439-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109%2F17482960802651717"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs13311-010-0011-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.62.5.464"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.59.6.629"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0278-2626%2891%2990002-P"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F119.1.319"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-009-5371-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02411377"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080%2F17482960701249340"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1044%2F1058-0360%282007%2F025%29"}],"container-title":["Case Reports in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/349895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/349895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:13:00Z","timestamp":1745431980000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000349895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,7]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000349895","archive":["Portico"],"relation":{},"ISSN":["1662-680X"],"issn-type":[{"value":"1662-680X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,7]]}}}