{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:53Z","timestamp":1745469233040,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>To evaluate macular thickness in eyes with mild nonproliferative diabetic retinopathy (NPDR), patients with diabetes type 2, NPDR level 20 or 35, and without evidence of clinical macular edema underwent best-corrected visual acuity assessment, color fundus photography and Stratus optical coherence tomography. Mean center point thickness (CPT) and mean central subfield (CSF) thickness were compared with those of a healthy control population. 410 eyes\/patients aged 61.2 \u00b1 8.3 years, and with glycosylated hemoglobin of 7.9 \u00b1 1.5% were included. Mean CPT and CSF were 186.6 \u00b1 28.4 and 215.2 \u00b1 25 \u00b5m, respectively, significantly increased compared to healthy subjects (p &lt; 0.001). CSF thickness was abnormally increased in 17.6% of the patients, with values within the normal range in 79.5%, and abnormally decreased in 2.9%. CPT and CSF thickness were significantly thicker in men. No systemic factors showed a significant association. A significant increase in the macular thickness was found in eyes\/patients with mild NPDR without clinical macular edema; however, only 17.6% of the eyes\/patients had abnormally increased values and less than 3% abnormally decreased values.<\/jats:p>","DOI":"10.1159\/000350593","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T14:21:18Z","timestamp":1366986078000},"page":"181-186","source":"Crossref","is-referenced-by-count":9,"title":["Macular Thickness Measured by Stratus Optical Coherence Tomography in Patients with Diabetes Type 2 and Mild Nonproliferative Retinopathy without Clinical Evidence of Macular Edema"],"prefix":"10.1159","volume":"229","author":[{"given":"Isabel","family":"Pires","sequence":"first","affiliation":[]},{"given":"Ana Rita","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Sandrina","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Concei\u00e7\u00e3o","family":"Lobo","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2013,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050120030015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.3.330"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.12.020"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)93601-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790311.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.06.028"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0514"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.10.055"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.119"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2008.01769.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.12.025"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.09.025"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.11"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701466"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.12.036"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181a2c1a7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.06.042"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4774"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.2.193"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420190068008"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.11.1631"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7598"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.2.282"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.53"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.111534"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5041"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8997"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/350593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/350593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:19:32Z","timestamp":1745432372000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000350593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000350593","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"type":"print","value":"0030-3755"},{"type":"electronic","value":"1423-0267"}],"subject":[],"published":{"date-parts":[[2013]]}}}