{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:35:44Z","timestamp":1777415744642,"version":"3.51.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To examine the relationship between subclinical diabetic macular edema (DME) and the development of clinically significant macular edema (CSME) in nonproliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A prospective, monocenter, observational study was designed to follow patients\/eyes with type 2 diabetes and NPDR (Early Treatment Diabetic Retinopathy Study levels 20 and 35) with no prior laser treatment for 2 years or until development of CSME. Ophthalmologic examinations, including best-corrected visual acuity, fundus photography and optical coherence tomography (OCT), were performed at baseline, 6 months and a final visit. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 348 patients completed study follow-up; 26 eyes developed CSME. Six out of 32 eyes\/patients presenting subclinical DME at baseline developed CSME (18.7%), while 20 out of 316 eyes without subclinical DME developed CSME (6.3%). Eyes\/patients with subclinical DME presented a risk for DME progression 3.686 times higher than that of eyes\/patients without subclinical DME (95% confidence interval 1.221-7.988). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Subclinical DME in eyes with NPDR identified by center point thickness measured on a Stratus OCT is a good predictor of CSME development.<\/jats:p>","DOI":"10.1159\/000354550","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T10:51:10Z","timestamp":1380106270000},"page":"201-206","source":"Crossref","is-referenced-by-count":16,"title":["Subclinical Macular Edema as a Predictor of Progression to Clinically Significant Macular Edema in Type 2 Diabetes"],"prefix":"10.1159","volume":"230","author":[{"given":"Isabel","family":"Pires","sequence":"first","affiliation":[]},{"given":"Ana Rita","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Sandrina","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Concei\u00e7\u00e3o","family":"Lobo","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Cunha-Vaz","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2013,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0514"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.10.055"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.3.330"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.06.042"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.53"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.11"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.08.038"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050120030015"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.12.025"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11055"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182111669"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.2.211"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8997"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/354550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/354550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:46:38Z","timestamp":1745433998000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000354550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000354550","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}