{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:42:11Z","timestamp":1774467731052,"version":"3.50.1"},"reference-count":32,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Purpose:<\/i><\/b> To characterize factors that may be associated with optimal or suboptimal response to ranibizumab intravitreal injections in diabetic macular edema (DME). <b><i>Methods:<\/i><\/b> Fifty-nine eyes with DME treated with ranibizumab were included. All underwent best-corrected visual acuity (BCVA) assessment and optical coherence tomography (OCT) at baseline, 3 and 6 months. Central retinal thickness (CRT) was assessed at each visit, and OCT images were classified according to their morphological patterns. <b><i>Results:<\/i><\/b> A mean BCVA increase of 4.78 and 5.52 letters, and a CRT decrease of 80.25 and 106.12 \u00b5m were found after 3 and 6 months of treatment (p < 0.001). BCVA improvement was found to be dependent on baseline BCVA and the degree of CRT decrease. Twenty-six eyes (44%) showing a CRT decrease \u226520% improved BCVA by 10.3 \u00b1 13.0 letters, whereas 33 eyes (56%) with a CRT decrease <20% had BCVA improvement of 1.8 \u00b1 7.2 letters (odds ratio = 3.31). <b><i>Conclusions:<\/i><\/b> The degree of CRT decrease obtained by spectral-domain OCT identifies well the optimal responders to intravitreal ranibizumab and predicts BCVA improvement after treatment.<\/jats:p>","DOI":"10.1159\/000355487","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T08:15:32Z","timestamp":1385108132000},"page":"16-22","source":"Crossref","is-referenced-by-count":24,"title":["Degree of Decrease in Central Retinal Thickness Predicts Visual Acuity Response to Intravitreal Ranibizumab in Diabetic Macular Edema"],"prefix":"10.1159","volume":"231","author":[{"given":"Ana Rita","family":"Santos","sequence":"first","affiliation":[]},{"given":"Sara 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