{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:06:14Z","timestamp":1776434774220,"version":"3.51.2"},"reference-count":24,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2013,11,2]],"date-time":"2013-11-02T00:00:00Z","timestamp":1383350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,11,2]],"date-time":"2013-11-02T00:00:00Z","timestamp":1383350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<b><i>Background\/Aims:<\/i><\/b> Citrate is an effective anticoagulant during continuous renal replacement therapy (CRRT). Previous studies showed raised parathyroid hormone (PTH) levels when aiming for serum ionized calcium [Ca<sub>i<\/sub>] between 0.8 and 1.1 mmol\/l. Our objective was to assess whether citrate-based CRRT with physiologic target systemic [Ca<sub>i<\/sub>] between 1.12 and 1.20 mmol\/l could maintain stable PTH levels. <b><i>Methods:<\/i><\/b> Measurement of intact PTH (PTHi) in 30 consecutive critically ill patients treated with citrate-based CRRT. <b><i>Results:<\/i><\/b> Thirty patients [mean age: 70.4 (SD 11.3) years; 56.7% males] were enrolled. Mean serum [Ca<sub>i<\/sub>] was 1.16 mmol\/l (SD 0.09), 1.13 mmol\/l (SD 0.09), 1.17 mmol\/l (SD 0.05) and 1.16 mmol\/l (SD 0.04) at baseline, 12, 24 and 48 h, respectively (p = 0.29). Median PTHi levels (interquartile range) at baseline, 12, 24 and 48 h were 66.5 (43-111), 109 (59.5-151.5), 88.5 (47-133) and 85 pg\/ml (53-140), respectively. The differences between baseline and 12 h and across all time points were statistically not significant (p = 0.16 and p = 0.49, respectively). In a mixed-effects model, each 0.1 mmol\/l increase in serum [Ca<sub>i<\/sub>] was associated with a 31.2% decrease in PTHi (p < 0.001). Results were unchanged after adjustment for age, gender, magnesium, phosphate, arterial pH and time spent on CRRT. <b><i>Conclusions:<\/i><\/b> Maintaining systemic [Ca<sub>i<\/sub>] within the physiologic range was associated with stable PTHi levels.<\/jats:p>","DOI":"10.1159\/000355860","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T08:16:30Z","timestamp":1383552990000},"page":"124-131","source":"Crossref","is-referenced-by-count":18,"title":["Maintaining Normal Levels of Ionized Calcium during Citrate-Based Renal Replacement Therapy Is Associated with Stable Parathyroid Hormone Levels"],"prefix":"10.1159","volume":"124","author":[{"given":"M\u00e1rio","family":"Raimundo","sequence":"first","affiliation":[]},{"given":"Siobhan","family":"Crichton","sequence":"additional","affiliation":[]},{"given":"Katie","family":"Lei","sequence":"additional","affiliation":[]},{"given":"Barnaby","family":"Sanderson","sequence":"additional","affiliation":[]},{"given":"John","family":"Smith","sequence":"additional","affiliation":[]},{"given":"John","family":"Brooks","sequence":"additional","affiliation":[]},{"given":"Josephine","family":"Ng","sequence":"additional","affiliation":[]},{"given":"Joanna","family":"Lemmich Smith","sequence":"additional","affiliation":[]},{"given":"Catherine","family":"McKenzie","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Beale","sequence":"additional","affiliation":[]},{"given":"Helen","family":"Dickie","sequence":"additional","affiliation":[]},{"given":"Marlies","family":"Ostermann","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2013,11,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2FCCM.0b013e3181953c5e"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfq575"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00342.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-003-2047-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-011-2438-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-005-0044-y"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc9358"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fkisup.2012.1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-002-1443-y"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2004.09.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000101853"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2362.1998.00391.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00003246-200001000-00015"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2FCCM.0b013e3181a00a92"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1213%2F01.ANE.0000132780.87036.F5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00003246-200204000-00020"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.114.4.954"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.114.4.1122"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2000.00912.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1475-097X.1990.tb00082.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-100-6-1703"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pone.0040242"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.75.1.145"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bone.2011.05.014"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:13:15Z","timestamp":1745431995000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,2]]},"references-count":24,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2013,12,1]]},"published-print":{"date-parts":[[2013,12,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000355860","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,2]]}}}