{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:01:09Z","timestamp":1772578869561,"version":"3.50.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Leydig cell testicular tumors are very rare in children. They can present as gonadotropin-independent precocious puberty due to excess androgen secretion. We report the case of an 8-year-old boy with isosexual precocity whose hormonal investigation showed luteinizing hormone-independent testosterone hypersecretion. Although no palpable mass was present, scrotal ultrasound revealed a testicular tumor. Testis-sparing tumor resection was performed and the histopathology analysis showed a Leydig cell tumor. After surgery the testosterone levels remained high and further examination showed gonadotropin-dependent precocious puberty, which is believed to be likely caused by the activation of the hypothalamic-pituitary axis due to a long-term exposition to sex steroids. He is currently being treated with a long-acting gonadotropin-releasing hormone analog and the process of sexual precocity has until now been suppressed.<\/jats:p>","DOI":"10.1159\/000358084","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T06:14:42Z","timestamp":1409120082000},"page":"133-137","source":"Crossref","is-referenced-by-count":10,"title":["Gonadotropin-Dependent Precocious Puberty in an 8-Year-Old Boy with Leydig Cell Testicular Tumor"],"prefix":"10.1159","volume":"82","author":[{"given":"Rita","family":"Santos-Silva","sequence":"first","affiliation":[]},{"given":"Artur","family":"Bonito-V\u00edtor","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Campos","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Fontoura","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2014,5,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2007.10.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.26-9-341"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198503000-00002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/1066896906292452"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542\/pir.27-10-373"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.19.19"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.3.1052"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412304"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.039"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1420150"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199810000-00014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.04.021"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000023323"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.03.014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80084-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1985.tb14602.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2001.14.9.1679"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02338.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1986.tb01757.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000151598"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/9781119968153.ch6"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4127"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:34:11Z","timestamp":1745433251000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,8,1]]},"published-print":{"date-parts":[[2014,8,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000358084","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}