{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:56:35Z","timestamp":1768827395897,"version":"3.49.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Objective: To assess the prognostic significance of iron deficiency (ID) in a chronic heart failure (CHF) outpatient population. Methods and Results: We prospectively evaluated 127 patients with stable CHF and left ventricular ejection fraction \u226445%. Clinical and analytical data as well as information regarding the occurrence of the composite endpoint of overall mortality and nonfatal cardiovascular events were assessed. Among the 127 patients enrolled [81% men, median age: 62 years (25th-75th percentile: 53-68)], 46 (36%) patients had ID. Women, patients with higher plasma brain natriuretic peptide levels (&gt;400 pg\/ml) and with right ventricular systolic dysfunction presented ID more frequently (p &lt; 0.05 for all). At 225 \u00b1 139 days of follow-up, the composite endpoint occurred in 15 (12%) patients. It was more frequent in ID (24 vs. 5%, p = 0.001) and anemic patients (25 vs. 8%, p = 0.014). In a Cox regression analysis, ID was associated with a higher likelihood of composite endpoint occurrence (HR 5.00, 95% CI 1.59-15.78, p = 0.006). In a multivariable analysis adjusted for clinical variables, including the presence of anemia, ID remained a significant predictor of the composite endpoint (HR 5.38, 95% CI 1.54-18.87, p = 0.009). Conclusion: In a CHF outpatient population, ID carried a higher risk of unfavorable outcome, irrespectively of the presence of anemia.<\/jats:p>","DOI":"10.1159\/000358377","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T11:16:57Z","timestamp":1402399017000},"page":"320-326","source":"Crossref","is-referenced-by-count":45,"title":["Iron Deficiency Status Irrespective of Anemia: A Predictor of Unfavorable Outcome in Chronic Heart Failure Patients"],"prefix":"10.1159","volume":"128","author":[{"given":"In\u00eas","family":"Rangel","sequence":"first","affiliation":[]},{"given":"Alexandra","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Carla","family":"de Sousa","sequence":"additional","affiliation":[]},{"given":"S\u00e9rgio","family":"Leite","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Campelo","sequence":"additional","affiliation":[]},{"given":"Elisabete","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Amorim","sequence":"additional","affiliation":[]},{"given":"Brenda","family":"Moura","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Silva Cardoso","sequence":"additional","affiliation":[]},{"given":"Maria J\u00falia","family":"Maciel","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2014,6,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31828124ad"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052622.51963.FC"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.061"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq158"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2006.12.003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2011.08.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs377"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs017"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908355"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs104"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.036"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.040"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.029"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-4-200608150-00004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.582577"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.01.017"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.960906"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.083"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2010.05.009"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358377","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crd\/article-pdf\/128\/4\/320\/3894051\/000358377.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crd\/article-pdf\/128\/4\/320\/3894051\/000358377.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:36:41Z","timestamp":1745433401000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,7,1]]},"published-print":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000358377","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}