{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:24:39Z","timestamp":1773923079180,"version":"3.50.1"},"reference-count":39,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating, interstitial lung disease, with few therapeutic options. IPF is characterized by pulmonary restriction, dyspnea, hypoxemia, exercise intolerance and poor quality of life (QOL). Objectives: We aimed to examine the effect of exercise training (ET) on clinical outcomes in IPF patients. Methods: A randomized controlled study included thirty-two IPF patients (aged 68 \u00b1 8 years) who were allocated either to the ET group (n = 15), participating in a 12-week, twice-weekly 60-min supervised ET-based pulmonary rehabilitation program, or to a control group (n = 17) continuing with regular medical treatment alone. Cardiopulmonary exercise test, 6-min walking distance (6MWD) test, 30-second chair-stand test, pulmonary function tests, dyspnea and QOL were assessed at baseline and at the end of the 12-week intervention. Results: Significant differences were observed between the ET and the control groups in raw mean deltas (\u0394 = post- - pre-intervention): \u03946MWD, 81 m, p &lt; 0.001; \u0394VO2 peak, 2.6 ml\/kg\/min, p = 0.002; \u0394work rate, 22 W, p &lt; 0.001; \u0394anaerobic threshold, 3.1 ml\/kg\/min, p &lt; 0.001, and \u0394FVC % predicted, 6%, p = 0.038. Dyspnea, QOL and 30-second chair-stand were also improved significantly following the program. Conclusions: ET improves exercise tolerance, functional capacity, pulmonary function, dyspnea and QOL in patients with IPF, suggesting a short-term treatment efficacy for clinical improvement, and should be considered the standard care for IPF.<\/jats:p>","DOI":"10.1159\/000367899","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T07:24:58Z","timestamp":1414481098000},"page":"378-388","source":"Crossref","is-referenced-by-count":130,"title":["Exercise Training-Based Pulmonary Rehabilitation Program Is Clinically Beneficial for Idiopathic Pulmonary Fibrosis"],"prefix":"10.1159","volume":"88","author":[{"given":"Baruch","family":"Vainshelboim","sequence":"first","affiliation":[]},{"given":"Jose","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Liora","family":"Yehoshua","sequence":"additional","affiliation":[]},{"given":"Israela","family":"Weiss","sequence":"additional","affiliation":[]},{"given":"Benjamin Daniel","family":"Fox","sequence":"additional","affiliation":[]},{"given":"Oren","family":"Fruchter","sequence":"additional","affiliation":[]},{"given":"Mordechai 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