{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:35:14Z","timestamp":1772818514870,"version":"3.50.1"},"reference-count":29,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To evaluate long-term results and predictors of efficacy in patients with macular edema due to retinal vein occlusion (RVO) treated with intravitreal ranibizumab in a clinical practice setting. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The clinical records of patients with a minimum follow-up of 3 years were retrospectively analyzed. Sixteen eyes with branch RVO (BRVO) and 16 with central RVO (CRVO) were included. All patients performed cross-sectional evaluation with best-corrected visual acuity (BCVA), spectral domain optical coherence tomography and fluorescein angiography. The foveal avascular zone (FAZ) was assessed and microstructural morphology of the retina was characterized. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Follow- up was 42.9 \u00b1 9.0 and 44.8 \u00b1 8.0 months in the CRVO and BRVO groups, respectively. Patients with CRVO received on average 6.9 injections, with a final VA gain of 8.3 \u00b1 15.0 letters (p = 0.05). BRVO eyes had on average 5.9 injections, with a final VA gain of 1.6 \u00b1 21.0 letters (p &gt; 0.05). The FAZ area remained stable in both groups (p &gt; 0.05). Baseline BCVA and disruption of the retinal pigment epithelium (RPE) were predictors of final BCVA (p = 0.001 and 0.011, respectively). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Although functional outcomes were inferior to those reported in clinical trials, ranibizumab was satisfactory in the long-term treatment of macular edema secondary to RVO and was not associated with increased macular ischemia. Final BCVA depends on baseline BCVA and RPE integrity.<\/jats:p>","DOI":"10.1159\/000440848","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T22:03:46Z","timestamp":1446761026000},"page":"10-18","source":"Crossref","is-referenced-by-count":24,"title":["Treatment of Retinal Vein Occlusion with Ranibizumab in Clinical Practice: Longer-Term Results and Predictive Factors of Functional Outcome"],"prefix":"10.1159","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4596-0913","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Farinha","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-0483","authenticated-orcid":false,"given":"Jo\u00e3o 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Luz","family":"Cachulo","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Pires","sequence":"additional","affiliation":[]},{"given":"Rufino","family":"Silva","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.05.039"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03909.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070020060029"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040110020"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000327391"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.10"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.08.016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e3283524148"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.021"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.022"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.02.022"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.02.038"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.038"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.03.028"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181feccc0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.08.013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.308"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S60893"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.032"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301087"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S37544"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.04.008"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.02.022"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/464218"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.032"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.008"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.234"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.233"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000191"}],"container-title":["Ophthalmic 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