{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:28:41Z","timestamp":1747193321689,"version":"3.40.5"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To characterize the relevance of macular thickness changes in the inner and outer rings in the progression of macular edema in eyes\/patients with diabetes type 2. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 374 type 2 diabetic patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20-35) were included in a 12-month prospective observational study to identify retinopathy progression. Retinal thickness analyses were performed in 194 eyes\/patients using Cirrus SD- OCT and 166 eyes\/patients using Spectralis SD-OCT. The DRCR.net classification of subclinical and clinical macular edema was used. A composite grading of macular edema is proposed in this study. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 317 eyes\/patients completed the study. SD-OCT identified clinical macular edema in 24 eyes\/patients (6.7%) and subclinical macular edema in 104 eyes\/patients (28.9%) at baseline. Increased thickness of the central subfield is the best predictor for the development of clinical macular edema, with 85.7% sensitivity and 71.9% specificity (OR: 2.57, 95% CI: 0.82-7.99). However, the involvement of the inner and outer rings is a cumulative predictor of progression to clinical macular edema (OR: 8.69, 95% CI: 2.85-26.52). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; A composite OCT grading of macular edema taking into account the retinal thickness changes in the inner and outer macular rings offers a simple way to characterize macular edema, with added clinical value.<\/jats:p>","DOI":"10.1159\/000441110","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T22:01:31Z","timestamp":1447106491000},"page":"19-25","source":"Crossref","is-referenced-by-count":4,"title":["Relevance of Retinal Thickness Changes in the OCT Inner and Outer Rings to Predict Progression to Clinical Macular Edema: An Attempt of Composite Grading of Macular Edema"],"prefix":"10.1159","volume":"55","author":[{"given":"Stela","family":"Vujosevic","sequence":"first","affiliation":[]},{"given":"Monica","family":"Varano","sequence":"additional","affiliation":[]},{"given":"Catherine","family":"Egan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-0659","authenticated-orcid":false,"given":"Sobha","family":"Sivaprasad","sequence":"additional","affiliation":[]},{"given":"Geeta","family":"Menon","sequence":"additional","affiliation":[]},{"given":"Ali","family":"Erginay","sequence":"additional","affiliation":[]},{"given":"Frank D.","family":"Verbraak","sequence":"additional","affiliation":[]},{"given":"Henrik","family":"Lund-Andersen","sequence":"additional","affiliation":[]},{"given":"Jose 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