{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:41Z","timestamp":1745469161881,"version":"3.40.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Soft tissue sarcomas (STSs) are heterogeneous tumors displaying multiple and complex molecular abnormalities with no specific pattern. Despite current therapeutic advances, the patients with STS still have a poor outcome, which makes it necessary to find out new prognostic markers. The Raf kinase inhibitory protein (RKIP) has been associated with prognosis in several human neoplasms; however, its role in STS is unknown. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In the present study RKIP expression was assessed by immunohistochemistry in a series of 87 STSs, and its expression profile was associated with the patients' pathological parameters. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We found that RKIP is expressed in the cytoplasm of the great majority of cases, and absent in only approximately 18% of cases (16\/87). Importantly, we observed that loss of RKIP expression was associated with poor outcome, constituting an independent prognostic marker. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This is the first study assessing RKIP expression levels in STS. We showed that loss of RKIP expression is present in a small subset of cases; however, its absence was associated with poor survival and may be a potential marker for STS prognosis.<\/jats:p>","DOI":"10.1159\/000441227","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T22:02:48Z","timestamp":1455055368000},"page":"41-46","source":"Crossref","is-referenced-by-count":6,"title":["Raf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sarcomas"],"prefix":"10.1159","volume":"83","author":[{"given":"Olga","family":"Martinho","sequence":"first","affiliation":[]},{"given":"Marcelo","family":"Campos","sequence":"additional","affiliation":[]},{"given":"Guilherme","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Valter","family":"Penna","sequence":"additional","affiliation":[]},{"given":"Em\u00edlio C.","family":"Curcelli","sequence":"additional","affiliation":[]},{"given":"Marcus 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