{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:39:31Z","timestamp":1768451971519,"version":"3.49.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T00:00:00Z","timestamp":1449100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T00:00:00Z","timestamp":1449100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Purpose:<\/i><\/b> To compare the efficacy and safety of intravitreal ranibizumab (IVR) in monotherapy or associated with panretinal photocoagulation (PRP) versus conventional PRP, for high-risk proliferative diabetic retinopathy (PDR) without vitreoretinal traction. <b><i>Procedures:<\/i><\/b> Multicenter randomized trial, with 3 treatment arms: PRP versus IVR alone and PRP + IVR combined treatment. Follow-up was performed at months 3, 6 and 12. <b><i>Results:<\/i><\/b> Thirty-five subjects were randomized and 32 used for analysis. Complete regression of neovessels elsewhere occurred in 100% (PRP + IVR), 75% (IVR) and 69.2% (PRP) and for neovessels of the disk in 44.4% (PRP + IVR), 37.5% (IVR) and 30.8% (PRP). During the 1-year duration of treatment, there was no need for laser rescue treatment in IVR-treated eyes. <b><i>Conclusions:<\/i><\/b> This trial suggests that the use of IVR is safe and may have a beneficial effect in the treatment of eyes with high-risk PDR. <b><i>Message:<\/i><\/b> Ranibizumab appears to have a place in the treatment of PDR.<\/jats:p>","DOI":"10.1159\/000442026","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T22:01:17Z","timestamp":1449093677000},"page":"34-41","source":"Crossref","is-referenced-by-count":25,"title":["Ranibizumab for High-Risk Proliferative Diabetic Retinopathy: An Exploratory Randomized Controlled Trial"],"prefix":"10.1159","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3511-1515","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Figueira","sequence":"first","affiliation":[]},{"given":"Rufino","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Henriques","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Caldeira Rosa","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"La\u00edns","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Melo","sequence":"additional","affiliation":[]},{"given":"Sandrina","family":"Gon\u00e7alves Nunes","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Cunha-Vaz","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2015,12,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e31819fd84a"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300674"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312203"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02010.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(81)34978-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32085-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/728325"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318042d32c"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31819a5fc2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.05.064"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000246884.76018.63"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/267643"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000348605"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0202"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000363"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.4154"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(13)38009-9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(13)38011-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10290"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4103\/2229-3485.83221"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-563-3_2"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442026","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:05:46Z","timestamp":1745431546000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000442026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,3]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,1]]},"published-print":{"date-parts":[[2016,1,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000442026","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,3]]}}}