{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T14:40:56Z","timestamp":1768920056771,"version":"3.49.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To assess and describe sequential morphological changes in the choroidal neovascularization (CNV) net using optical coherence tomography angiography (OCTA) in patients undergoing treatment with intravitreal antivascular endothelial growth factor (VEGF). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Prospective cohort study. OCTA was performed sequentially: before (t0), 1 h (t1), 1 week (t2) and 1 month after the injection (t3), using Avanti RTVue XR equipped with the AngioVue\u00ae software (Optovue, Calif., USA). All images were classified by two independent graders. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Ten eyes of 10 patients, with a mean age of 72.4 \u00b1 10.5 years, were included. CNV morphology was described as tree-like in 5 eyes, glomerular in 1 and fragmented in 4. A fibrovascular capsule surrounding the CNV net was found in 4 eyes and a feeder trunk was noticed in 6. No changes were observed at t1. Loss of peripheral capillaries, vessel fragmentation and decreased vessel density were evident in 8 eyes at t2. The CNV capillary density and the peripheral anastomosis increased in all of these at t3. Two eyes remained unchanged through the whole length of follow-up. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Significant changes in the CNV net can be observable in OCTA at least 1 week after intravitreal anti-VEGF. The safety of frequent examinations may provide a method of gauging treatment effects.<\/jats:p>","DOI":"10.1159\/000442671","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T22:01:23Z","timestamp":1452117683000},"page":"145-151","source":"Crossref","is-referenced-by-count":21,"title":["Sequential Morphological Changes in the CNV Net after Intravitreal Anti-VEGF Evaluated with OCT Angiography"],"prefix":"10.1159","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-0483","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Marques","sequence":"first","affiliation":[]},{"given":"Jos\u00e9 Filipe","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Maria Luz","family":"Cachulo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3511-1515","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Figueira","sequence":"additional","affiliation":[]},{"given":"Rufino","family":"Silva","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2016,1,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000371584"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.11.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.04.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.04.012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2011.0221"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-198902930-00011"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1957169"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.A0820126"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.01.029"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20141118-03"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000635"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1364\/OE.20.004710"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.4.001909"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20140925-01"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.01.034"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.80"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000766"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000879"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000846"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.06.030"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3616"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000433547"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000836"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.05.015"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000189797"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000379754"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/138070"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.06.020"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.017"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.09.012"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442671","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:11:04Z","timestamp":1745431864000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000442671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,2,1]]},"published-print":{"date-parts":[[2016,2,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000442671","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}