{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:34:52Z","timestamp":1758634492580,"version":"3.40.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Purpose:<\/i><\/b> To analyze the effect of anti-vascular endothelial growth factor (VEGF) agents on intraocular pressure (IOP) in patients with neovascular age-related macular degeneration (AMD). <b><i>Materials and<\/i><\/b><b><i>Methods:<\/i><\/b> This is a retrospective study that included 72 patients treated unilaterally with anti-VEGF agents according to a pro re nata regimen. Fellow noninjected eyes (n = 72) were used as controls. IOP variation and the development of sustained ocular hypertension (OHT) were assessed both in the injected and in the fellow eyes. <b><i>Results:<\/i><\/b> While the final IOP was not significantly different between the 2 groups, sustained OHT developed in 4.2% of the injected eyes and 1.4% of the controls. In the study group, no significant IOP variation was noted during follow-up in patients receiving \u226420 injections, but there was a significant increase in IOP with time in more frequently treated patients (p = 0.041). Comparison of both subgroups demonstrated that patients receiving >20 injections suffered significantly greater IOP variation (p = 0.034) during follow-up, and that these patients tended to require IOP-lowering treatment more frequently (p = 0.090). <b><i>Conclusion:<\/i><\/b> Multiple anti-VEGF injections lead to an increase in IOP, although this variation is not sufficient to cause development of OHT in the majority of patients.<\/jats:p>","DOI":"10.1159\/000444395","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T21:03:27Z","timestamp":1459890207000},"page":"30-34","source":"Crossref","is-referenced-by-count":6,"title":["Long-Term Effect of Anti-VEGF Agents on Intraocular Pressure in Age-Related Macular Degeneration"],"prefix":"10.1159","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-4597","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Beato","sequence":"first","affiliation":[]},{"given":"Ana Catarina","family":"Pedrosa","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Pinheiro-Costa","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Freitas-da-Costa","sequence":"additional","affiliation":[]},{"given":"Manuel S.","family":"Falc\u00e3o","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Melo","sequence":"additional","affiliation":[]},{"given":"S\u00e9rgio","family":"Estrela-Silva","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Falc\u00e3o-Reis","sequence":"additional","affiliation":[]},{"given":"\u00c2ngela M.","family":"Carneiro","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2016,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.099598"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.07.007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S64721"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-012-0031-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000036"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32834ff41d"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.08.011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318261a6f7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2009.0076"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.180729"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318217ffde"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2014.11.004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-1981-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000346397"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000520"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31820d7d19"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20120618-01"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.04.029"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02240.x"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444395","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/444395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:47:12Z","timestamp":1745430432000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000444395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,5,28]]},"published-print":{"date-parts":[[2016,5,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000444395","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2016]]}}}