{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:35:46Z","timestamp":1774600546691,"version":"3.50.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Cholangiocarcinoma is the second most frequent primitive liver malignancy and is responsible for 3% of the malignant gastrointestinal neoplasms. The aims of this study were to determine the association of serum levels of CA 19-9 at diagnosis with other clinical data and serum liver function tests and to identify possible factors that influence the survival rates during follow-up. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Retrospective observational study of 89 patients with a diagnosis of cholangiocarcinoma followed at the Department of Gastroenterology during 5 years. Statistical analyses were performed using SPSS version 20.0. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Patients were followed up for a median time of 127 days (IQR: 48-564), and the median age at diagnosis was 71.0 years (IQR: 62.0-77.5). The median survival rate was 14.0 months (IQR: 4.3-23.7), and the mortality rate was 79%. Patients with CA 19-9 levels \u2265103 U\/L had lower albumin levels and higher levels of alanine aminotransferase and &amp;#x03B3;-glutamyltransferase. CA 19-9 levels \u2265103 U\/L were associated with a higher probability of metastization (&lt;i&gt;p&lt;\/i&gt; = 0.001) and lower rates of treatment with curative intent (&lt;i&gt;p&lt;\/i&gt; = 0.024). In a multivariate analysis, CA 19-9 levels &lt;103 U\/L and surgery were independent predictors of survival. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Predictive factors for overall survival were identified, namely presence of metastasis, surgery, and chemotherapy. CA 19-9 levels \u2265103 U\/L were predictive factors for survival and metastization.<\/jats:p>","DOI":"10.1159\/000452691","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T22:01:31Z","timestamp":1489528891000},"page":"114-121","source":"Crossref","is-referenced-by-count":26,"title":["CA 19-9 as a Marker of Survival and a Predictor of Metastization in Cholangiocarcinoma"],"prefix":"10.1159","volume":"24","author":[{"given":"Rosa","family":"Coelho","sequence":"first","affiliation":[]},{"given":"Marco","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Eduardo","family":"Rodrigues-Pinto","sequence":"additional","affiliation":[]},{"given":"H\u00e9lder","family":"Cardoso","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Filipe","family":"Vilas-Boas","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Santos-Antunes","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Costa-Maia","sequence":"additional","affiliation":[]},{"given":"Guilherme","family":"Macedo","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2017,2,23]]},"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452691","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/452691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:24:08Z","timestamp":1745429048000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000452691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,5,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000452691","archive":["Portico"],"relation":{},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"value":"2341-4545","type":"print"},{"value":"2387-1954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}