{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:28:06Z","timestamp":1745468886902,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Introduction:<\/i><\/b> Clinical trials and subsequent meta-analyses showed advantages of non-vitamin K antagonists oral anticoagulants (NOACs) over vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation. The impact of preadmission anticoagulation in acute ischaemic stroke (AIS) has not been established. <b><i>Objective:<\/i><\/b> To compare functional outcome of patients with AIS with preadmission NOACs vs. VKAs. <b><i>Methods:<\/i><\/b> A retrospective analysis was conducted on consecutive AIS patients under oral anticoagulation (VKAs or NOACs) admitted in 4 Portuguese hospitals within a period of 30 months. Two primary outcomes were defined and compared between VKA and NOAC groups: symptomatic intracerebral hemorrhage transformation (sICH) and modified Rankin Scale (mRS) at 3 months. <b><i>Results:<\/i><\/b> Four hundred sixty-nine patients were included, of whom 332 (70.8%) were treated with VKA and 137 (29.2%) with NOAC. Patients\u2019 median age was 78.0 and 234 (49.9%) were male. NOAC-treated patients had a higher median CHA<sub>2<\/sub>DS<sub>2<\/sub>-VASc score than those under VKA (5.0 vs. 4.0, <i>p<\/i>\u00a0= 0.023). The two primary outcomes showed no statistical differences between the VKAs\u2019 group and the NOACs\u2019 group (sICH: 5.4 vs. 5.4% [<i>p<\/i>\u00a0= 0.911]; mRS at 3 months: 3.0 vs. 3.0 [<i>p<\/i>\u00a0= 0.646], respectively). <b><i>Conclusion:<\/i><\/b> Preadmission anticoagulation with NOACs in AIS has a functional impact similar to that of VKAs.<\/jats:p>","DOI":"10.1159\/000486755","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T22:01:34Z","timestamp":1518127294000},"page":"108-112","source":"Crossref","is-referenced-by-count":0,"title":["Portuguese Observational Study of Ischaemic Stroke in Patients Medicated with Non-Vitamin K Antagonist Oral Anticoagulants"],"prefix":"10.1159","volume":"79","author":[{"given":"Jos\u00e9","family":"Beato-Coelho","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o\u00a0Pedro","family":"Marto","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9\u00a0Nuno","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udia","family":"Marques-Matos","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Calado","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Pinho","sequence":"additional","affiliation":[]},{"given":"Elsa","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Viana-Baptista","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Sargento-Freitas","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70536-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000185696.73938.e0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.4948"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12587"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022913"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:37:16Z","timestamp":1745426236000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":6,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2018,3,13]]},"published-print":{"date-parts":[[2018,3,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000486755","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5868087","asserted-by":"subject"}]},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"type":"print","value":"0014-3022"},{"type":"electronic","value":"1421-9913"}],"subject":[],"published":{"date-parts":[[2018]]}}}