{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:27:21Z","timestamp":1770676041460,"version":"3.49.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Purpose:<\/i><\/b> To investigate the influence of the vitreoretinal interface on the outcomes of different ranibizumab regimens for exudative age-related macular degeneration. <b><i>Methods:<\/i><\/b> We conducted a retrospective subanalysis of 2 prospective clinical trials. Patients were treated with ranibizumab for 12 months according to 3 different regimens: pro-re-nata (PRN), treat and extend (T&amp;E), and monthly. Vitreoretinal interface was assessed for absence (group ON) or presence (group OFF) of posterior vitreous detachment (PVD). <b><i>Results:<\/i><\/b> We included 64 eyes from 64 patients. Visual improvement was poorer for group ON (0.3 \u00b1 10.7 letters) than for group OFF (9.2 \u00b1 13.3; <i>p<\/i> = 0.007). A significant difference in letters of improvement between groups was observed in the PRN cohort (ON: \u20135.0 \u00b1 12.9; OFF: 11.4 \u00b1 11.9; <i>p<\/i> = 0.003), but not in the cohorts with monthly (ON: 5.7 \u00b1 7.8; OFF: 7.9 \u00b1 15.2; <i>p<\/i> = 0.735) or T&amp;E (ON: 4.3 \u00b1 4.3; OFF: 7.8 \u00b1 11.1; <i>p<\/i> = 0.424) treatment. <b><i>Conclusion:<\/i><\/b> The negative impact of absence of PVD is regimen dependent, with monthly dosing providing similar outcomes to PVD patients. In the absence of PVD (group ON), PRN should be avoided, and T&amp;E might be an alternative.<\/jats:p>","DOI":"10.1159\/000488010","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T21:01:23Z","timestamp":1525726883000},"page":"29-36","source":"Crossref","is-referenced-by-count":6,"title":["Influence of the Vitreoretinal Interface on the Treatment with Anti-VEGF for Exudative Age-Related Macular Degeneration"],"prefix":"10.1159","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-6818","authenticated-orcid":false,"given":"Pedro","family":"Gil","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o\u00a0","family":"Gil","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"La\u00edns","sequence":"additional","affiliation":[]},{"given":"Eduardo\u00a0Nery\u00a0Rossi","family":"Camilo","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Raimundo","sequence":"additional","affiliation":[]},{"given":"Maria\u00a0da\u00a0Luz","family":"Cachulo","sequence":"additional","affiliation":[]},{"given":"Rufino","family":"Silva","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.07.024"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.04.027"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.09.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.01.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.10.003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.05.032"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318295f72e"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-014-0333-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.04.015"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.02.031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000446585"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2016.11.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.10.1475"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200502000-00001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30716-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001142"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000313814"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.04.028"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.192385"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.04.028"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2266-y"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000635"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000879"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:48:27Z","timestamp":1745426907000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,6,19]]},"published-print":{"date-parts":[[2018,6,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000488010","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}