{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T14:02:03Z","timestamp":1777125723793,"version":"3.51.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Beta-lactam allergy is overdiagnosed. Diagnosis of penicillin allergy has been associated with a greater use of hospital resources and an increased risk of antibiotic-resistant infections, although this issue remains poorly studied in children. We aimed to compare patient characteristics and use of hospital resources in hospitalized children with and without a record of penicillin allergy. <b><i>Methods:<\/i><\/b> We identified all hospitalizations in children labelled as being allergic to penicillin in a database containing all hospitalizations in Portuguese public hospitals between 2000 and 2014, and compared these with a similar number of age-, sex-, and main diagnosis-matched hospitalizations without a penicillin allergy label. Comparisons were made for length of hospital stay, comorbidities (Charlson Comorbidity Index), in-hospital mortality, and hospitalization costs. <b><i>Results:<\/i><\/b> We identified 1,718 hospitalizations corresponding to children labelled as penicillin-allergic. Compared with patients without such a label, these children had longer hospital stays (mean 5 vs. 4 days, <i>p<\/i> = 0.03) and a higher comorbidity index (mean 0.11 vs. 0.09, <i>p &#x3c;<\/i> 0.001). Hospitalization costs were also higher (EUR 2,071 vs. 1,798), but the difference was not significant (<i>p<\/i> = 0.12). <b><i>Conclusions:<\/i><\/b> Hospitalizations of children labelled as allergic to penicillin are associated with longer hospital stays, more comorbidities, and a tendency towards higher hospitalization costs. An accurate diagnosis of penicillin allergy based on clinical history and confirmatory tests is therefore essential in all paediatric patients.<\/jats:p>","DOI":"10.1159\/000488857","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T21:01:22Z","timestamp":1527022882000},"page":"234-238","source":"Crossref","is-referenced-by-count":26,"title":["Hospitalizations in Children with a Penicillin Allergy Label: An Assessment of Healthcare Impact"],"prefix":"10.1159","volume":"176","author":[{"given":"Bernardo","family":"Sousa-Pinto","sequence":"first","affiliation":[]},{"given":"Lu\u00eds","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"given":"Alberto","family":"Freitas","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds","family":"Delgado","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12155"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-011-8279-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12565"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0476-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2016.1191319"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02870.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2013.852957"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.03.009"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.028"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01638.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw462"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3468"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.026"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/all.12350"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.07.013"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03774.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112479"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.04.021"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202438"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.11.002"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12493"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:23:25Z","timestamp":1745425405000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":24,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2018,7,11]]},"published-print":{"date-parts":[[2018,7,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000488857","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}