{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:57:34Z","timestamp":1768982254052,"version":"3.49.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed Hub"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; The present study aimed to assess functional and structural benefits of erythropoietin (EPO) when administered subconjunctivally in the retina of glaucomatous rats using electroretinography (ERG) and retinal thickness (RT) measurements. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Glaucoma was experimentally induced in 26 Wistar Hannover albino rats. Animals were divided into 2 groups of 13 animals each: a treated group receiving a unique subconjunctival injection of 1,000 IU of EPO and a control group receiving a saline solution. In each group, 7 animals were used for retinal function evaluation (ERG) and 6 animals were used for retinal structural evaluation (histology). RT was measured, dorsally and ventrally, at 500 \u03bcm (RT1) and at 1,500 \u03bcm (RT2) from the optic nerve. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Retinal function evaluation: for both scotopic and photopic conditions, ERG wave amplitudes increased in the treated group. This increase was statistically significant (&lt;i&gt;p&lt;\/i&gt; &lt; 0.05) in photopic conditions. Structural evaluation: for both locations RT1 and RT2, the retinas were significantly (&lt;i&gt;p&lt;\/i&gt; &lt; 0.05) thicker in the treated group. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Subconjunctival EPO administration showed beneficial effects both on retinal structure and on retinal function in induced glaucoma in albino rats. This neuroprotective effect should be applied in other animal species.<\/jats:p>","DOI":"10.1159\/000488970","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T21:16:54Z","timestamp":1531430214000},"page":"1-11","source":"Crossref","is-referenced-by-count":16,"title":["Functional and Structural Effects of Erythropoietin Subconjunctival Administration in Glaucomatous Animals"],"prefix":"10.1159","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-2743","authenticated-orcid":false,"given":"Ana Paula","family":"Resende","sequence":"first","affiliation":[]},{"given":"Serge G.","family":"Rosolen","sequence":"additional","affiliation":[]},{"given":"Telmo","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Berta","family":"S\u00e3o Braz","sequence":"additional","affiliation":[]},{"given":"Esmeralda","family":"Delgado","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1070"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S80445"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e31817841e5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2009.23"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(95)80056-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0832"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms130911102"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2007.20.5.1120219"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401504"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000089951"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.94"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0721"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000369885"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/02713680500320729"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/02713680802366602"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.156794"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2008.0021"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.07.025"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2367-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000444327"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(05)80131-9"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-005-7344-y"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.joco.2016.01.008"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00523"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3980\/j.issn.2222-3959.2011.01.09"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2016.12.001"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-017-0399-y"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00584.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.10.025"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.06.013"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2014.06.003"}],"container-title":["Biomedicine Hub"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:24:31Z","timestamp":1745425471000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,13]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,1,28]]},"published-print":{"date-parts":[[2018,8,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000488970","archive":["Portico"],"relation":{},"ISSN":["2296-6870"],"issn-type":[{"value":"2296-6870","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,13]]}}}