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There are specific groups that were identified as high-risk groups for anal squamous cell carcinoma and anal human papillomavirus infection, namely HIV-positive patients, men who have sex with men, women with genital tract neoplasia, and solid organ transplant recipients. Condylomas have classically been considered to be a benign lesion, with an exception made for the Buschke-Loewenstein tumor, but several publications have shown that a high percentage of condylomas harbor high-grade lesions. Due to the similarities between anal and cervical carcinogenesis, anal cancer screening based on anal cytology and referral to high-resolution anoscopy, in case of abnormalities, have been advocated. Testing for anal human papillomavirus is not routinely done in anal cancer screening, because of the very high prevalence in high-risk populations. The large majority of anal cancers are squamous cell carcinomas (SCC), and around 90% are attributed to human papillomavirus. Human papillomavirus positivity in anal SCC seems to have a prognostic value, with better survival in those patients with positive tumors. Prophylactic vaccination has been shown to be important for prevention of anal human papillomavirus-related lesions.<\/jats:p>","DOI":"10.1159\/000491815","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T22:00:31Z","timestamp":1553205631000},"page":"118-123","source":"Crossref","is-referenced-by-count":12,"title":["New Insights into the Role of Human Papillomavirus in Anal Cancer and Anal Wart Development"],"prefix":"10.1159","volume":"63","author":[{"given":"Andreia","family":"Albuquerque","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-8373","authenticated-orcid":false,"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/ 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