{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:48:33Z","timestamp":1774385313946,"version":"3.50.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The implementation of population screening for cervical lesions in rural areas has been particularly challenging for a variety of reasons, including geographic isolation, limited access to medical care, lack of awareness of cancer risks, lower education levels, and embarrassment about having the clinical examination. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This study was designed to evaluate the use of self-sampling for human papillomavirus (HPV) screening in the rural communities served by our hospital. To develop the study group, we trained a local police officer who was already interacting with the rural community to explain cancer risks and the ease of self-sampling to the women. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We identified a study group of 386 women, of whom 369 (95.6%) agreed to participate in the study. To test for high-risk HPV, we performed the Cobas PCR test, and of 340 valid samples, 45 (12.2%) were positive for at least 1 of the high-risk HPV subtypes. All positively tested women were referred for colposcopy and Papanicolaou testing. The follow-up biopsies showed that 40% had low-grade intraepithelial neoplasia (CIN1), 6.6% had high-grade intraepithelial neoplasia (CIN2\/3), and 4.4% had squamous cell carcinoma. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Self-collection for HPV testing by women living in isolated communities is highly efficient and has potential for cost-effective screening by taking advantage of existing support networks, such as the local police service.<\/jats:p>","DOI":"10.1159\/000493333","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T08:53:19Z","timestamp":1551430399000},"page":"7-15","source":"Crossref","is-referenced-by-count":7,"title":["Implementation of a Cervical Cancer Screening Strategy Using HPV Self-Sampling for Women Living in Rural Areas"],"prefix":"10.1159","volume":"64","author":[{"given":"J\u00falio\u00a0Cesar","family":"Possati-Resende","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-9521","authenticated-orcid":false,"given":"Fabiana\u00a0de\u00a0Lima","family":"Vazquez","sequence":"additional","affiliation":[]},{"given":"Naitielle\u00a0de\u00a0Paula","family":"Pantano","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-6469","authenticated-orcid":false,"given":"Jos\u00e9\u00a0Humberto\u00a0Tavares\u00a0Guerreiro","family":"Fregnani","sequence":"additional","affiliation":[]},{"given":"Edmundo\u00a0Carvalho","family":"Mauad","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-9752","authenticated-orcid":false,"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<55::AID-IJC11>3.0.CO;2-U"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/19.2.189"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa044278"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1363\/3514709"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70570-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12549"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1590\/S1414-81452009000200020"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2014.04.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2002.01170.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2005.14.721"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00835.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102010000500023"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.07.092"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/493333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/493333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:50:34Z","timestamp":1745427034000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000493333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,28]]},"references-count":15,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2020,1,7]]},"published-print":{"date-parts":[[2019,12,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000493333","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,28]]}}}