{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:32:38Z","timestamp":1762522358110,"version":"3.40.5"},"reference-count":0,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Purpose: Ulcerative colitis (UC) can be managed with immunomodulation or surgery. We aimed to understand whether these strategies had a different impact on patients\u2019 health-related quality of life (HRQoL). Methods: This was a retrospective, cross-sectional study: patients who had a moderate to severe UC episode that prompted the utilization of immunomodulatory drugs or surgery were invited to complete a generic (short form [36] health survey [SF-36]) and a disease-specific (inflammatory bowel disease questionnaire [IBDQ]) survey. Results: We included 157 patients, 65 (41.4%) surgically treated. The therapeutic procedure had a minimal impact on HRQoL: only the social dimension of the IBDQ and the physical function component of the SF-36 were significantly different between the study arms \u2013 lower for the surgically treated patients. The type of surgery had no impact, but the occurrence of pouchitis, namely, in a chronic form, was associated with a lower HRQoL. Regression analysis confirmed surgery as an independent predictor of lower scores in the social dimension of the IBDQ (\u20134.646, 95% CI \u20136.953 to \u20132.339) and in the physical functioning (\u20139.622, 95% CI \u201317.061 to \u20132.183) and physical role functioning (\u20133.669, 95% CI \u20137.339 to 0.001) dimensions of the SF36. Conclusions: Although usually feared by patients, surgery has a limited impact on UC patients HRQoL when compared to medical management with immunomodulatory drugs.<\/jats:p>","DOI":"10.1159\/000501823","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T21:02:08Z","timestamp":1569272528000},"page":"631-637","source":"Crossref","is-referenced-by-count":2,"title":["Health-Related Quality of Life in Patients with Moderate to Severe Ulcerative Colitis: Surgical Intervention versus Immunomodulatory Therapy"],"prefix":"10.1159","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-6124","authenticated-orcid":false,"given":"Francisco","family":"Portela","sequence":"first","affiliation":[]},{"given":"Paula","family":"Ministro","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"de\u00a0Deus","sequence":"additional","affiliation":[]},{"given":"Marilia","family":"Cravo","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Cotter","sequence":"additional","affiliation":[]},{"given":"Gabriela","family":"Duque","sequence":"additional","affiliation":[]},{"given":"Frederico","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Bruno","family":"Rosa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-9542","authenticated-orcid":false,"given":"Pedro\u00a0Lopez","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Claudia\u00a0Camila","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[]},{"name":"Portuguese\u00a0IBD\u00a0Study\u00a0Group\u00a0(GEDII)","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2019,9,6]]},"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/101\/5\/631\/4028192\/000501823.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/101\/5\/631\/4028192\/000501823.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:45:47Z","timestamp":1745423147000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,6]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,9,11]]},"published-print":{"date-parts":[[2020,9,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000501823","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.9777635","asserted-by":"subject"}]},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2019,9,6]]}}}