{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:29:48Z","timestamp":1747193388962,"version":"3.40.5"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kompass Dermatol"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Fortgeschrittene Plattenepithelkarzinome der Kopf-Hals-Region, die sich nach lokoregion\u00e4rer Behandlung und mehreren systemischen Therapielinien als refrakt\u00e4r erweisen, stellen eine schwierige therapeutische Herausforderung dar. Der vorliegende Fallbericht schildert ein Erfolgsbeispiel und beschreibt erstmals die Anwendung einer photodynamischen Therapie (PDT) mit Redaporfin gefolgt von einer Immun-Checkpoint-Inhibition mit einem Antik\u00f6rper gegen PD1. Der betreffende Patient hatte einen umfangreichen Tumor am Mundboden, der nach Chirurgie, Strahlentherapie und zahlreichen Linien systemischer Therapie weiter progredierte. Mit der Redaporfin-PDT wurde s\u00e4mtliches erkennbares Tumorgewebe zerst\u00f6rt, und die anschlie\u00dfende Anwendung eines Immun-Checkpoint-Inhibitors erm\u00f6glichte ein anhaltendes vollst\u00e4ndiges Ansprechen. Dieser Fall ist ein Beispiel f\u00fcr die Wirkung dieser Kombinationstherapie und k\u00f6nnte den Weg f\u00fcr eine neue therapeutische Modalit\u00e4t ebnen.<\/jats:p>","DOI":"10.1159\/000503077","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T22:00:34Z","timestamp":1574373634000},"page":"215-219","source":"Crossref","is-referenced-by-count":0,"title":["Behandlung von Kopf-Hals-Tumoren mittels photodynamischer Therapie mit Redaporfin: ein klinischer Fallbericht"],"prefix":"10.1159","volume":"7","author":[{"given":"Julio","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"Eurico","family":"Monteiro","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Sarmento","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-5655","authenticated-orcid":false,"given":"L\u00facio Lara","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Juliana","family":"Santos","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2014.01.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-697-9_18"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"ref4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-017-9694-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0515"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/014556131509400208"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2014.10.001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3006-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.09.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300449"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201304202"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798354"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9020019"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b09112"}],"container-title":["Kompass Dermatologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:57:44Z","timestamp":1745423864000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000503077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,11,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000503077","archive":["Portico"],"relation":{},"ISSN":["2296-5424","2296-536X"],"issn-type":[{"type":"print","value":"2296-5424"},{"type":"electronic","value":"2296-536X"}],"subject":[],"published":{"date-parts":[[2019]]}}}