{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:26:13Z","timestamp":1745468773467,"version":"3.40.4"},"reference-count":40,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The role of antiretroviral therapy (ART) for Hepatitis C viral load (HCV-VL) and liver fibrosis is poorly understood. This study aimed at evaluating the influence of ART on HCV-VL and liver fibrosis in human immunodeficiency virus (HIV)\/HCV-coinfected patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We conducted a retrospective cohort study of HIV\/HCV-coinfected patients followed at a tertiary university hospital. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In total, 143 patients were included. In 61 patients, ART initiation was accompanied by an increase in HCV-VL and a decrease in HIV viral load (HIV-VL), whereas ART suspension led to a decrease in HCV-VL and an increase in HIV-VL. Among the 55 HIV-suppressed patients who switched to a raltegravir (RAL)-containing regimen, median HCV-VL levels decreased significantly, while switching to a rilpivirine-containing regimen did not yield a significant reduction. &lt;b&gt;&lt;i&gt;Discussion:&lt;\/i&gt;&lt;\/b&gt; If the \u00adtreatment of chronic hepatitis starts before ART, ART initiation should be delayed as much as possible. If ART has been started, it is advisable to wait 1 year before initiating chronic hepatitis treatment. RAL as the third agent in an ART regimen could be beneficial in HIV\/HCV-coinfected patients, in comparison to other antiretroviral drugs. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The start and the suspension of ART significantly interferes with HCV-VL in HIV\/HCV-coinfected patients.<\/jats:p>","DOI":"10.1159\/000503631","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T22:00:47Z","timestamp":1574892047000},"page":"182-190","source":"Crossref","is-referenced-by-count":1,"title":["The Influence of Antiretroviral Therapy on Hepatitis C Virus Viral Load and Liver Fibrosis in Human Immunodeficiency Virus-Coinfected Patients: An Observational Study"],"prefix":"10.1159","volume":"62","author":[{"given":"Jorge","family":"Soares","sequence":"first","affiliation":[]},{"given":"Ant\u00f3nio","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9","family":"Silva-Pinto","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Almeida","sequence":"additional","affiliation":[]},{"given":"Carmela","family":"Pi\u00f1eiro","sequence":"additional","affiliation":[]},{"given":"Ros\u00e1rio","family":"Serr\u00e3o","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Sarmento","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01934.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-9-34"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i34.12132"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.15.1632"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i41.5225"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32830e6d51"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300409"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21351"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.06.014"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000275"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000490056"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.025"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000221689.77220.42"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1086\/342388"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1086\/315529"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X09339079"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318061b5d9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)91712-P"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i47.8963"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i25.8018"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.07.006"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33023"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr083"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2014.12.006"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.04.005"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2738"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2011.00933.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp446"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr093"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328336e9b3"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt386"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu515"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02684.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1086\/599371"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2012.02953.x"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks130"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1177\/1060028015576180"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.863708"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.998997"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503631","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/503631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:02:20Z","timestamp":1745424140000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000503631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":40,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2020,7,23]]},"published-print":{"date-parts":[[2020,7,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000503631","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"type":"print","value":"0300-5526"},{"type":"electronic","value":"1423-0100"}],"subject":[],"published":{"date-parts":[[2019]]}}}