{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T18:24:55Z","timestamp":1749320695930,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> Central serous chorioretinopathy (CSCR) is a chorioretinal disorder resulting from choroidal hyperpermeability. Its comorbidities as hypertension, coronary disease, and psychological stress, suggest that it might reflect a more generalized vascular dysfunction. <b><i>Objectives:<\/i><\/b> The aim of the study was to assess the cerebrovascular regulation integrity, using cerebral autoregulation (CA), carbon dioxide vasoreactivity (VR), and neurovascular coupling (NVC) in CSCR. <b><i>Methods:<\/i><\/b> This observational pilot study included 20 CSCR patients and 14 age- and sex-matched controls. A State-Trait Anxiety Inventory (STAI) inquiry was full-filled. Continuous measurement of cerebral blood flow velocity (CBFV), arterial blood pressure, heart rate, and end-tidal carbon dioxide was performed. VR was assessed during hypercapnia (inhaling carbogen gas) and hypnocapnia (hyperventilation). For NVC, the CBFV relative increase during mental activation using the N-Back Task was calculated. <b><i>Results:<\/i><\/b> No significant differences in systemic hemodynamic parameters, CA or VR, were found between both groups. During the NVC performance, the average CBFV rise during mental stress was significantly lower in CSCR (<i>p<\/i> = 0.011). A significant negative correlation was found between STAI scores and NVC. <b><i>Conclusions:<\/i><\/b> CSCR patients presented a significantly impaired cerebral NVC compared to controls, supporting the theory of a potential systemic vascular dysfunction. Stress could be related to this NVC impairment. <\/jats:p>","DOI":"10.1159\/000509553","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T21:00:31Z","timestamp":1592600431000},"page":"446-454","source":"Crossref","is-referenced-by-count":5,"title":["Cerebral Neurovascular Coupling Impairment in Central Serous Chorioretinopathy"],"prefix":"10.1159","volume":"65","author":[{"given":"Susana","family":"Penas","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[]},{"given":"Gilberto","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Ana Marta","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Angela M.","family":"Carneiro","sequence":"additional","affiliation":[]},{"given":"Am\u00e2ndio","family":"Rocha-Sousa","sequence":"additional","affiliation":[]},{"given":"Elsa","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Fernando M.","family":"Falc\u00e3o-Reis","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0b013e31823ff9a6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000331"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182953df4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0158-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.05.003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000159"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16360"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050123"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1246"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303945"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301810"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.12.003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15626425"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.1.h233"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2014.02.001"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22433"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-018-0739-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310398"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2006.08.002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17696100"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401811111"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0129-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21825"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16245099"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0212-2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32981-2"},{"key":"ref28"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:47:55Z","timestamp":1745423275000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,8,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000509553","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}