{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:03:50Z","timestamp":1775747030121,"version":"3.50.1"},"reference-count":29,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The main risk factor for the development of cervical cancer (CC) is persistent infection by human papillomavirus (HPV) oncogenic types. In order to persist, HPV exhibits a plethora of immune evasion mechanisms. PI3\/Elafin (Peptidase Inhibitor 3) is an endogenous serine protease inhibitor involved in epithelial protection against pathogens. PI3\/Elafin\u2019s role in CC is still poorly understood. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; In the present study, we addressed PI3\/Elafin protein detection in 123 CC samples by immunohistochemistry and mRNA expression in several datasets available at Gene Expression Omnibus and The Cancer Genome Atlas platforms. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We observed that PI3\/Elafin is consistently downregulated in CC samples when compared to normal tissue. Most of PI3\/Elafin-positive samples exhibited this protein at the plasma membrane. Besides, high PI3\/Elafin expression at the cellular membrane was more frequent in in situ stages I + II than in invasive cervical tumor stages III + IV. This indicates that PI3\/Elafin expression is gradually lost during the CC progression. Of note, advanced stages of CC were more frequently associated with a more intense PI3\/Elafin reaction in the nuclei and cytoplasm. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our results suggest that PI3\/Elafin levels and subcellular localization may be used as a biomarker for CC severity. <\/jats:p>","DOI":"10.1159\/000512010","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T22:01:32Z","timestamp":1607032892000},"page":"165-174","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of Elafin Immunohistochemical Expression as Marker of Cervical Cancer Severity"],"prefix":"10.1159","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-9752","authenticated-orcid":false,"given":"Adhemar","family":"Longatto-Filho","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-6469","authenticated-orcid":false,"given":"Jos\u00e9 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