{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:21:28Z","timestamp":1776399688326,"version":"3.51.2"},"reference-count":53,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Gastric carcinogenesis progresses from normal mucosa, atrophic\/metaplastic gastritis, and dysplasia to adenocarcinoma. MicroRNAs (miRNAs) regulate DNA expression and have been implicated; however, their role is not fully established. &lt;b&gt;&lt;i&gt;Aims:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to characterize plasma and tissue expression of several miRNAs in gastric carcinogenesis stages. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Single-center cross-sectional study in 64 patients: 19 controls (normal mucosa); 15 with extensive atrophic\/metaplastic gastritis; and 30 with early gastric neoplasia (EGN). Seven miRNAs (miR-21, miR-146a, miR-181b, miR-370, miR-375, miR 181b, and miR-490) were quantified by real time-qPCR in peripheral blood and endoscopic biopsy samples. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2\u201314-times higher than controls). We observed a significant underexpression of miR-146a and miR-370 in atrophic\/metaplastic gastritis (86 and 66% decrease, &lt;i&gt;p&lt;\/i&gt; = 0.008 and &lt;i&gt;p&lt;\/i&gt; = 0.001) and in EGN (89 and 62% reduction, &lt;i&gt;p&lt;\/i&gt; = 0.034 and &lt;i&gt;p&lt;\/i&gt; = 0.032) compared with controls. There were no differences between lesions and nonneoplastic mucosa and no dysregulation of plasma miRNAs. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; We found significant dysregulation of 5 miRNAs in gastric carcinogenesis, suggesting a tumor suppressor role for miR-146a and miR-370 and oncogenic potential for miR-21, miR-181, and miR-490. These changes happen diffusely in the gastric mucosa, suggesting a high-risk field defect, which may influence these patients\u2019 surveillance. <\/jats:p>","DOI":"10.1159\/000515548","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T21:00:41Z","timestamp":1626469241000},"page":"338-350","source":"Crossref","is-referenced-by-count":5,"title":["Original Article: MicroRNA Dysregulation in the Gastric Carcinogenesis Cascade: Can We Anticipate Its Role in Individualized Care?"],"prefix":"10.1159","volume":"88","author":[{"given":"In\u00eas","family":"Pita","sequence":"first","affiliation":[]},{"given":"Diogo","family":"Lib\u00e2nio","sequence":"additional","affiliation":[]},{"given":"Francisca","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Ana 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