{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:40:20Z","timestamp":1778557220182,"version":"3.51.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Gastrointestinal neuroendocrine tumors (GI-NETs) are being more frequently diagnosed and treated by endoscopic resection (ER) techniques. However, comparison studies of the different ER techniques or long-term outcomes are rarely reported. Methods: This was a single-center retrospective study analyzing short and long-term outcomes after ER of gastric, duodenum, and rectal GI-NETs. Comparison between standard EMR (sEMR), EMR with a cap (EMRc), and endoscopic submucosal dissection (ESD) was made. Results: Fifty-three patients with GI-NET (25 gastric, 15 duodenal, and 13 rectal; sEMR = 21; EMRc = 19; ESD = 13) were included in the analysis. Median tumor size was 11 mm (range 4\u201320), significantly larger in the ESD and EMRc groups compared to the sEMR group (p &lt; 0.05). Complete ER was possible in all cases with 68% histological complete resection (no difference between the groups). Complication rate was significantly higher in the EMRc group (EMRc 32%, ESD 8%, and EMRs 0%, p = 0.01). Local recurrence occurred in only one patient, and systemic recurrence in 6%, with size \u2265 12 mm being a risk factor for systemic recurrence (p = 0.05). Specific disease-free survival after ER was 98%. Conclusion: ER is a safe and highly effective treatment particularly for less than 12 mm luminal GI-NETs. EMRc is associated with a high complication rate and should be avoided. sEMR is an easy and safe technique that is associated with long-term curability, and it is probably the best therapeutic option for most luminal GI-NETs. ESD appears to be the best option for lesions that cannot be resected en bloc with sEMR. Multicenter, prospective randomized trials should confirm these results.<\/jats:p>","DOI":"10.1159\/000521654","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T18:00:35Z","timestamp":1647280835000},"page":"98-106","source":"Crossref","is-referenced-by-count":9,"title":["Endoscopic Resection of Gastrointestinal Neuroendocrine Tumors: Long-Term Outcomes and Comparison of Endoscopic Techniques"],"prefix":"10.1159","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7308-3295","authenticated-orcid":false,"given":"Pedro","family":"Pimentel-Nunes","sequence":"first","affiliation":[]},{"given":"Raquel","family":"Ortig\u00e3o","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds Pedro","family":"Afonso","sequence":"additional","affiliation":[]},{"given":"Rui Pedro","family":"Bastos","sequence":"additional","affiliation":[]},{"given":"Diogo","family":"Lib\u00e2nio","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-6850","authenticated-orcid":false,"given":"M\u00e1rio","family":"Dinis-Ribeiro","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-10-0152"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.093"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1200140"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2018.1498120"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/a-1062-8897"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/253860"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.07.029"}],"updated-by":[{"DOI":"10.1159\/000528278","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000}}],"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/pjg\/article-pdf\/30\/2\/98\/4021531\/000521654.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pjg\/article-pdf\/30\/2\/98\/4021531\/000521654.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:42:44Z","timestamp":1745408564000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000521654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,14]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,3,16]]},"published-print":{"date-parts":[[2023,8,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000521654","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1159\/000528278","asserted-by":"object"}]},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"value":"2341-4545","type":"print"},{"value":"2387-1954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,14]]}}}