{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:25:36Z","timestamp":1771561536350,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> The OPTIPARK study confirmed the effectiveness and safety of opicapone as adjunct therapy to levodopa in patients with Parkinson\u2019s disease (PD) and motor fluctuations under real-world conditions. The aim of this sub-analysis was to evaluate opicapone in the German patient cohort of OPTIPARK in order to provide country-specific data. <b><i>Methods:<\/i><\/b> OPTIPARK was an open-label, single-arm study conducted in routine clinical practice across Germany and the UK. Patients with PD and motor fluctuations received once-daily opicapone 50 mg for 3 months in addition to levodopa. The primary endpoint was Clinicians\u2019 Global Impression of Change (CGI-C). Secondary assessments included Patients\u2019 Global Impressions of Change (PGI-C), Unified Parkinson\u2019s Disease Rating Scale (UPDRS) I\u2013IV, Parkinson\u2019s Disease Questionnaire (PDQ-8), and Non-Motor Symptoms Scale (NMSS). This sub-analysis reports outcomes from the German patients only. <b><i>Results:<\/i><\/b> Overall, 363 (97.6%) of the 372 patients included in the German cohort received \u22651 dose of opicapone and 291 (80.2%) completed the study. Improvements on CGI-C and PGI-C were reported by 70.8% and 76.3% of patients, respectively. UPDRS scores improved for activities of daily living during OFF time by \u22123.3 \u00b1 4.5 points and motor scores during ON time by \u22125.3 \u00b1 7.9 points. PDQ-8 and NMSS scores also demonstrated improvements. Treatment emergent adverse events considered at least possibly related to opicapone occurred in 37.7% of patients, with most being of mild or moderate intensity. <b><i>Conclusion:<\/i><\/b> Opicapone added to levodopa in patients with PD and motor fluctuations was effective and generally well tolerated in routine clinical practice across Germany. <\/jats:p>","DOI":"10.1159\/000523771","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:00:37Z","timestamp":1648587637000},"page":"389-397","source":"Crossref","is-referenced-by-count":4,"title":["Opicapone Use in Clinical Practice across Germany: A Sub-Analysis of the OPTIPARK Study in Parkinson\u2019s Disease Patients with Motor Fluctuations"],"prefix":"10.1159","volume":"85","author":[{"given":"Heinz","family":"Reichmann","sequence":"first","affiliation":[]},{"given":"Karla","family":"Eggert","sequence":"additional","affiliation":[]},{"given":"Christian","family":"Oehlwein","sequence":"additional","affiliation":[]},{"given":"Tobias","family":"Warnecke","sequence":"additional","affiliation":[]},{"given":"Andrew J.","family":"Lees","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Kemmer","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-5078","authenticated-orcid":false,"given":"Patr\u00edcio","family":"Soares-da-Silva","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14119"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_460_18"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20279"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-016-1671-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.62.1_suppl_1.s31"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2174\/138920021705160324170558"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/161456"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170510143821"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-020-00778-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.157148"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e213"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13309"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1426"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-020-00187-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/08870449708406741"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12694"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26078"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.295"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23638"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-005-0072-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70068-7"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/523771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/523771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:54:43Z","timestamp":1745423683000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000523771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,9,20]]},"published-print":{"date-parts":[[2022,9,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000523771","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}