{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:47:05Z","timestamp":1772768825453,"version":"3.50.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2024]]},"abstract":"<b><i>Introduction:<\/i><\/b> Chronic atrophic gastritis may contribute to gastric polyps (GP) phenotype in familial adenomatous polyposis (FAP). Considering the high prevalence of <i>Helicobacter pylori<\/i> (HP) infection in Portugal, we aim to characterize GP in a series of Portuguese patients. <b><i>Methods:<\/i><\/b> In a retrospectively selected series of 53 FAP patients, clinical data and histopathological features of GP and background gastric mucosa were studied. SPSS (27.0) was used for statistical analysis. <b><i>Results:<\/i><\/b> Thirteen patients (24.5%) developed fundic gland polyps (FGP), seven (13.2%) gastric adenomas (GA), and ten (18.9%) both FGP and GA. Out of 100 GP, four were hyperplastic polyps, 58 FGP (24 with dysplasia), 35 intestinal-type GA (intGA), and three foveolar-type GA (fovGA). IntGA were larger (60% &gt;7 mm, <i>p<\/i> = 0.03), occurred predominantly in the distal stomach (66.7%, <i>p<\/i> = 0.024), in patients harboring gastric intestinal metaplasia (IM) (86.7%, <i>p<\/i> &lt; 0.001), and duodenal adenomas (86.7%, <i>p<\/i> &lt; 0.001). <b><i>Conclusion:<\/i><\/b> This is the first Western series showing high prevalence of intGA in FAP patients, comparable to Asian cohorts. HP infection and chronic atrophic gastritis\/intestinal metaplasia are likely responsible for this difference, with risk of neoplastic transformation and management implications. Biopsy\/excision of GP &gt;7 mm in the distal stomach and in patients harboring gastric intestinal metaplasia\/duodenal adenomas should be considered. <\/jats:p>","DOI":"10.1159\/000534571","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T23:30:11Z","timestamp":1697671811000},"page":"196-204","source":"Crossref","is-referenced-by-count":3,"title":["Gastric Polyps in Familial Adenomatous Polyposis Portuguese Patients: The First Western Cohort with Asian Features"],"prefix":"10.1159","volume":"91","author":[{"given":"Diana","family":"Baptista","sequence":"first","affiliation":[]},{"given":"Marco","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Monica","family":"Garrido","sequence":"additional","affiliation":[]},{"given":"Fabiana","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Morais","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Garcia-Pelaez","sequence":"additional","affiliation":[]},{"given":"Roberto","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Dina","family":"Leit\u00e3o","sequence":"additional","affiliation":[]},{"given":"Manuela","family":"Baptista","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Barbosa","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Carneiro","sequence":"additional","affiliation":[]},{"given":"Irene","family":"Gullo","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2023,10,18]]},"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/pat\/article-pdf\/91\/3\/196\/4237189\/000534571.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pat\/article-pdf\/91\/3\/196\/4237189\/000534571.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:48:29Z","timestamp":1745423309000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000534571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6,4]]},"published-print":{"date-parts":[[2024,6,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000534571","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.24721710","asserted-by":"subject"}]},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"value":"1015-2008","type":"print"},{"value":"1423-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]}}}