{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:50:08Z","timestamp":1761324608295,"version":"build-2065373602"},"reference-count":32,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"abstract":"<jats:p>Introduction: As Portugal exhibits some of the highest gastric cancer rates in Europe, optimizing the Helicobacter pylori eradication rate is imperative. We aimed to describe H. pylori treatment regimens in Portugal, within a real clinical practice setting. Methods: This is a prospective cohort study of the Portuguese patients diagnosed with H. pylori between May 2013 and December 2022, within the European Registry on Helicobacter pylori Management (Hp-EuReg). The demographic and clinical data, diagnostic methods, treatment regimens, and prescription trends with their effectiveness were analysed by modified intention-to-treat (mITT) and per-protocol (PP) analyses. Results: Overall, 700 cases, mainly from 2 centres (98% of cases), were included, with 59% females, with a mean age of 54 \u00b1 15 years. Treatment-na\u00efve patients encompassed 81% of cases. Overall compliance (&gt;90% drug intake) was reported in 99% of cases. Overall effectiveness was 87%, by both mITT and PP analyses. The triple PPI-clarithromycin-amoxicillin therapy decreased from 29% in 2013 to 0% in 2022. Conversely, both quadruple concomitant PPI-clarithromycin-amoxicillin-metronidazole and PPI-bismuth-metronidazole-tetracycline therapies were predominantly used from 2016 onwards, with PPI-bismuth-metronidazole-tetracycline representing 76% of all prescriptions in 2022, achieving an overall mITT effectiveness of 92% and 91%, respectively. Conclusion: In Portugal, concomitant quadruple therapy with PPI-clarithromycin-amoxicillin-metronidazole and bismuth quadruple with PPI-bismuth-metronidazole-tetracycline provided both optimal (&gt;90%) effectiveness, in line with results of other Southern European countries. <\/jats:p>","DOI":"10.1159\/000543179","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T12:00:22Z","timestamp":1734177622000},"page":"339-349","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of First-Line Empirical Treatment in Portugal: Data from the European Registry on Helicobacter pylori Management"],"prefix":"10.1159","volume":"32","author":[{"given":"Maria In\u00eas","family":"Viegas","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-8175","authenticated-orcid":false,"given":"Miguel","family":"Areia","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7904-6129","authenticated-orcid":false,"given":"Lu\u00eds","family":"Elvas","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Marcos-Pinto","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1906-9351","authenticated-orcid":false,"given":"Henrique","family":"Fernandes-Mendes","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Brito","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Saraiva","sequence":"additional","affiliation":[]},{"given":"Ana 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