{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T07:57:32Z","timestamp":1782028652001,"version":"3.54.5"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Doris Duke Charitable Foundation Clinical Scientist Development Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Paroxysmal Nocturnal Haemoglobinuria (PNH) results in a marked thrombophilic state by unknown mechanisms. Geographic differences in thrombosis incidence in PNH have been observed. We have reviewed 64 patients with \u201cClassic PNH\u201d from a single institution in order to determine the rate of thrombosis in different ethnic groups.When we compared African- Americans (n=11) and Latin-Americans (n=8) with other patients (n= 45), we found that African-American and Latin-American patients are at increased risk [Hazard ratio 3.66 (p=0.005) and 3.52, (p= 0.035) respectively by Cox regression]. Our data also suggest that this difference in the rate of thrombosis has an impact on length of survival.These findings demonstrate that ethnicity is a risk factor for thrombosis in PNH and have implications for decision-making regarding the management of these patients,including the prevention of thrombosis.<\/jats:p>","DOI":"10.1160\/th04-06-0391","type":"journal-article","created":{"date-parts":[[2004,12,8]],"date-time":"2004-12-08T09:20:55Z","timestamp":1102497655000},"page":"88-91","source":"Crossref","is-referenced-by-count":43,"title":["High incidence of thrombosis in African-American and Latin-American patients with Paroxysmal Nocturnal Haemoglobinuria"],"prefix":"10.1160","volume":"93","author":[{"given":"Howard","family":"Thaler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Luzzatto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Araten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,14]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH04-06-0391.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T19:49:30Z","timestamp":1540410570000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH04-06-0391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2017,12,5]]},"published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1160\/th04-06-0391","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}