{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:19:55Z","timestamp":1791901195514,"version":"4.3.4"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Caprini who kindly provided supplementary original data for the review"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Perioperative antithrombotic clinical regimens have reduced the incidence of postoperative deep venous thrombosis (DVT). Long-term effects of asymptomatic postoperative DVT have been studied in a number of clinical trials and the present review describes the clinical significance of asymptomatic postoperative DVT regarding the possible development of postthrombotic syndrome (PTS).We performed a systematic review of reference databases focusing upon studies including patients suspected of having postoperative DVT and reporting subsequent cases of PTS at the end of a well-defined follow-up period. The included studies were stratified according to type of screening method and applied statistics. Over-all evaluation included metaanalyses based upon the Cochrane software package. The overall relative risk of developing PTS was 1.58 (95% confidence intervals: 1.24 \u2013 2.02) in patients suffering from asymptomatic DVT as compared to patients without DVT ( p &lt; 0.0005).In conclusion, asymptomatic postoperative DVT is associated with an increased risk of late development of PTS. The finding emphasizes that postoperative DVT, diagnosed by means of well-defined objective measures, remains the correct scientific endpoint in trials evaluating the efficacy of preoperative antithrombotic treatment regimens.<\/jats:p>","DOI":"10.1160\/th04-09-0570","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T09:54:11Z","timestamp":1105091651000},"page":"236-241.","source":"Crossref","is-referenced-by-count":113,"title":["Asymptomatic postoperative deep vein thrombosis and the development of postthrombotic syndrome"],"prefix":"10.1160","volume":"93","author":[{"given":"Lars N.","family":"Jorgensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Crawford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peer","family":"Wille-J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0049-3848(00)00370-4","article-title":"Postthrombotic syndrome after primary event of deep venous thrombosis 10 to 20 years ago.","volume":"101","author":"S Ziegler","year":"2001","journal-title":"Thromb Res"},{"key":"ref2","first-page":"192","article-title":"The incidence of post-thrombotic syndrome.","volume":"144","author":"R Eichlisberger","year":"1994","journal-title":"Wien Med Wochenschr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000060611","article-title":"Postthrombotic syndrome.","volume":"27","author":"R Eichlisberger","year":"1999","journal-title":"Curr Probl Dermatol"},{"key":"ref4","first-page":"83","article-title":"Chronic venous disorders of the leg: epidemiology, outcomes, diagnosis and management. Summary of an evidencebased report of the VEINES task force. Venous Insufficiency Epidemiologic and Economic Studies.","volume":"18","author":"X Kurz","year":"1999","journal-title":"Int Angiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00019509-199708000-00014","article-title":"Incidence of thromboembolic complications after laparoscopic cholecystectomy: review of the lierature.","volume":"7","author":"F Lindberg","year":"1997","journal-title":"Surg Laparosc Endosc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"652","DOI":"10.5694\/j.1326-5377.1996.tb122233.x","article-title":"The incidence of deep venous thrombosis after laparoscopic cholecystectomy.","volume":"164","author":"MI Patel","year":"1996","journal-title":"Med J Aust"},{"key":"ref7","first-page":"423","article-title":"The clinical course of deep-vein thrombosis. Prospective longterm follow-up of 528 symptomatic patients.","volume":"82","author":"P Prandoni","year":"1997","journal-title":"Haematologica"},{"key":"ref8","first-page":"285","article-title":"Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Systematic reviews in health care: Meta-analysis in context.","author":"JJ Deeks","year":"2001","journal-title":"BMJ Books"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test.","volume":"315","author":"M Egger","year":"1997","journal-title":"BMJ"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/bmj.2.5917.468","article-title":"Sequealae of an 125I-fibrinogen detected thrombus.","volume":"2","author":"NL Browse","year":"1974","journal-title":"Br Med J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0883-5403(96)80105-7","article-title":"Does total hip arthroplasty predispose to chronic venous insufficiency?","volume":"11","author":"D Warwick","year":"1996","journal-title":"J Arthroplasty"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00000658-198302000-00015","article-title":"Venous function in the leg after postoperative thrombosis diagnosed with 125I-fibrinogen uptake test.","volume":"197","author":"A Lindhagen","year":"1983","journal-title":"Ann Surg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/bjs.1800710713","article-title":"Deep venous insufficiency after postoperative thrombosis diagnosed with 125I-labelled fibrinogen uptake test.","volume":"71","author":"A Lindhagen","year":"1984","journal-title":"Br J Surg"},{"key":"ref14","first-page":"527","article-title":"Late complications of asymptomatic deep venous thrombosis.","volume":"157","author":"M Andersen","year":"1991","journal-title":"Eur J Surg"},{"key":"ref15","first-page":"2259","article-title":"Postthrombotic syndrome after total hip arthroplasty.","author":"JA Caprini","year":"2001","journal-title":"Thromb Haemostas"},{"key":"ref16","first-page":"249","article-title":"A prospective 10-year study of the post-thrombotic syndrome in a surgical population.","volume":"70","author":"M Mudge","year":"1988","journal-title":"Ann R Coll Surg Engl"},{"key":"ref17","first-page":"57","article-title":"Clinical course and incidence of post-thrombophlebitic syndrome after profound asymptomatic deep vein thrombosis. Results of a transverse epidemiologic study.","volume":"45","author":"S Siragusa","year":"1997","journal-title":"Minerva Cardioangiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1001\/archinte.160.5.669","article-title":"Postthrombotic syndrome after hip or knee arthroplasty: a cross-sectional study.","volume":"160","author":"JS Ginsberg","year":"2000","journal-title":"Arch Intern Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00003086-198807000-00034","article-title":"Longterm clinical observations and venous functional abnormalities after asymptomatic venous thrombosis following total hip or knee arthroplasty.","volume":"232","author":"CW Francis","year":"1988","journal-title":"Clin Orthop"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.7326\/0003-4819-126-6-199703150-00006","article-title":"Cost of long-term complications of deep venous thrombosis of the lower extremities: an analysis of a defined patient population in Sweden.","volume":"126","author":"D Bergqvist","year":"1997","journal-title":"Ann Intern Med"},{"key":"ref21","first-page":"152","article-title":"Chronic venous insufficiency of the lower limbs and its socio-economic significance.","volume":"10","author":"MC Silva","year":"1991","journal-title":"Int Angiol"},{"key":"ref22","first-page":"161","article-title":"Socioeconomic impact of chronic venous insufficiency. An underestimated public health problem.","volume":"17","author":"OR Van den","year":"1998","journal-title":"Int Angiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1056\/NEJM198805053181805","article-title":"Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery.","volume":"318","author":"R Collins","year":"1988","journal-title":"N Engl J Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3109\/17453679808999043","article-title":"Commentary on thromboprophylaxis in hip replacement surgery.","volume":"69","author":"CJ Bulstrode","year":"1998","journal-title":"Acta Orthop Scand"},{"key":"ref25","first-page":"157","volume-title":"Why and how sources of heterogeneity should be investigated","author":"SG. 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