{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:39:39Z","timestamp":1761100779715},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hepatic veno-occlusive disease (VOD) is a severe complication after hematopoietic stem cell transplantation (HSCT). Recent studies, mainly in adults receiving HSCT, have identified an increase in the plasminogen activator inhibitor-1 (PAI-1) as a possible marker of VOD. To confirm this finding, the fibrinolytic, coagulation and liver function parameters were assayed before and weekly for 1 month after 61 HSCT performed in 53 consecutive children. Non-VOD patients had a slight increase in t-PA antigen, fibrinogen and P-selectin levels, as well as a mildly longer aPTT and a drop in antithrombin after HSCT. The 6 children with VOD (9.84%) had an early and significant increase in PAI-1 antigen and activity (p&lt; 0.0001), t-PA antigen (p&lt; 0.0001) and D-dimer (p&lt; 0.01) levels, and a decrease in plasminogen, \u03b12-antiplasmin and PT emerged 2(\u00b11) days before the clinical diagnosis of VOD by comparison with mean post-HSCT values in the non-VOD patients. Significant differences were also detected for these parameters and antithrombin levels between non-VOD and VOD patients soon after the clinical onset of VOD, whereas the rise in bilirubin levels became significant only later on. In conclusion, variations in fibrinolytic test findings after HSCT, and PAI-1 in particular, may facilitate the early diagnosis of VOD in pediatric patients after HSCT.<\/jats:p>","DOI":"10.1160\/th04-09-0621","type":"journal-article","created":{"date-parts":[[2005,2,10]],"date-time":"2005-02-10T13:37:48Z","timestamp":1108042668000},"page":"682-689","source":"Crossref","is-referenced-by-count":17,"title":["Role of fibrinolytic and clotting parameters in the diagnosis of liver veno-occlusive disease after hematopoietic stem cell transplantation in a pediatric population"],"prefix":"10.1160","volume":"93","author":[{"given":"Luca","family":"Spiezia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Cesaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Messina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Paris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Pillon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziella","family":"Saggiorato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pagnan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Girolami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Zanesco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Cella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Teresa Sartori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0268-960X(93)90023-W","article-title":"Hepatic venoocclusive disease after bone marrow transplant","volume":"7","author":"E Carreras","year":"1993","journal-title":"Blood Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1182\/blood.V85.11.3005.bloodjournal85113005","article-title":"The syndrome of hepatic veno-occlusive disease after marrow transplantation","volume":"85","author":"SJ Bearman","year":"1995","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7326\/0003-4819-118-4-199302150-00003","article-title":"Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients","volume":"118","author":"GB McDonald","year":"1993","journal-title":"Ann Intern Med"},{"key":"ref4","first-page":"3599","article-title":"Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation","volume":"92","author":"E Carreras","year":"1998","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/00007890-198712000-00011","article-title":"Venocclusive disease of the liver following bone marrow transplantation","volume":"44","author":"RJ Jones","year":"1987","journal-title":"Transplantation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1034\/j.1600-0609.2000.9r200.x","article-title":"Veno-occlusive disease of the liver after hemopoietic cell transplantation","volume":"64","author":"E Carreras","year":"2000","journal-title":"Eur J Haematol"},{"key":"ref7","first-page":"197","article-title":"Hepatic veno-occlusive disease \u2013 liver toxicity syndrome after bone marrow transplantation","volume":"10","author":"HM Shulman","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"ref8","first-page":"549","article-title":"Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules","volume":"127","author":"HM Shulman","year":"1987","journal-title":"Am J Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.1840040121","article-title":"Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors","volume":"4","author":"GB McDonald","year":"1984","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1182\/blood.V83.10.3036.3036","article-title":"Serum procollagen type III is an early and sensitive marker for venoocclusive disease of the liver in children undergoing bone marrow transplantation","volume":"83","author":"H Heikinheimo","year":"1994","journal-title":"Blood"},{"key":"ref11","first-page":"471","article-title":"N-terminal peptide of type III procollagen: a marker for the development of hepatic veno-occlusive disease after BMT and a basis for determining the timing of prophylactic heparin","volume":"11","author":"B Rio","year":"1993","journal-title":"Bone Marrow Transplant"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/10428199709114163","article-title":"Venocclusive disease of the liver after bone marrow transplantation: The role of hemostasis","volume":"25","author":"EM Faioni","year":"1997","journal-title":"Leuk Lymphoma"},{"key":"ref13","first-page":"135","article-title":"Changes in protein C, factor VII and endothelial markers after autologous bone marrow transplantation: possible implications in the pathogenesis of veno-occlusive disease","volume":"35","author":"A Barzabacchi","year":"1993","journal-title":"Nouv Rev Fr Hematol"},{"key":"ref14","first-page":"519","article-title":"Early hemostatic alterations following bone marrow transplantation: a prospective study","volume":"79","author":"AM Vannucchi","year":"1994","journal-title":"Haematologica"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1055\/s-0038-1648806","article-title":"Factor VIIa and other haemostatic variables following bone marrow transplantation","volume":"72","author":"P Collins","year":"1994","journal-title":"Thromb Haemost"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1182\/blood.V81.12.3458.3458","article-title":"Naturally occurring anticoagulants and bone marrow transplantation: plasma protein C predicts the development of venocclusive disease of the liver","volume":"81","author":"EM Faioni","year":"1993","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1182\/blood.V75.4.1011.1011","article-title":"Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation","volume":"75","author":"E Holler","year":"1990","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1016\/S0021-9258(17)43143-7","article-title":"Inactivation of tissue plasminogen activator in plasma. Demonstration of a complex with a new rapid inhibitor","volume":"259","author":"B Wiman","year":"1984","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1055\/s-0038-1661556","article-title":"Blood platelet plasminogen activator inhibitor: two different pools of endothelial cell type plasminogen activator inhibitor in human blood","volume":"55","author":"ED Sprengers","year":"1986","journal-title":"Thromb Haemost"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1055\/s-0038-1646997","article-title":"Insulin stimulates the synthesis of plasminogen activator inhibitor 1 by the human hepatocellular cell line HepG2","volume":"60","author":"MC Alessi","year":"1988","journal-title":"Thromb Haemost"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1182\/blood.V72.5.1467.1467","article-title":"Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo","volume":"72","author":"VW van Hinsbergh","year":"1988","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1046\/j.1538-7836.2003.00437.x","article-title":"Tissue- and agonist-specific regulation of human and murine plasminogen activator inhibitor-1 promoters in transgenic mice","volume":"1","author":"M Eren","year":"2003","journal-title":"J Thromb Haemost"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1055\/s-0038-1642655","article-title":"Plasminogen activator inhibitor 1 (PAI-1) in plasma: its role in thrombotic diseases","volume":"74","author":"B Wiman","year":"1995","journal-title":"Thromb Haemost"},{"key":"ref24","first-page":"747","article-title":"Parameters of the fibrinolytic system in patients undergoing BMT: Elevation of PAI-1 in veno-occlusive disease","volume":"14","author":"C Salat","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1182\/blood.V89.6.2184","article-title":"Plasminogen activator inhibitor-1 confirms the diagnosis of hepatic veno-occlusive disease in patients with hyperbilirubinemia after bone marrow transplant","volume":"89","author":"C Salat","year":"1997","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/1024533031000084231","article-title":"Role of plasminogen activator inhibitor-1 (PAI-1) levels in the diagnosis of BMT-associated hepatic veno-occlusive disease and monitoring of subsequent therapy with defibrotide","volume":"8","author":"M Kaleelrahman","year":"2003","journal-title":"Hematology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1046\/j.1365-2141.2002.03748.x","article-title":"Plasminogen activator inhibitor-1 is an independent diagnostic marker as well as severity predictor of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide","volume":"118","author":"JH Lee","year":"2002","journal-title":"Br J Haematol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1182\/blood-2002-04-1216","article-title":"Multiinstitutional use of defibrotide in 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without significant toxicity in a high-risk population and factors predictive of outcome","volume":"100","author":"PG Richardson","year":"2002","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/sj.bmt.1700760","article-title":"Changes in hemostatic parameters in hepatic veno-occlusive disease following bone marrow transplantation","volume":"19","author":"Y-D Park","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1056\/NEJM199203263261301","article-title":"A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation","volume":"326","author":"JL Goodman","year":"1992","journal-title":"N Engl J Med"},{"key":"ref31","first-page":"1122","article-title":"Defibrotide for the treatment of hepatic veno-occlusive disease: results of the European compassionate-use study","volume":"111","author":"R Chopra","year":"2000","journal-title":"Br J Haematol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1200\/JCO.1988.6.10.1562","article-title":"Regimen-related toxicity in patients undergoing bone marrow transplantation","volume":"6","author":"S Bearman I","year":"1988","journal-title":"J Clin Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000205234","article-title":"Gerinnungsphysiologishe schnellmethode zur bestimmung des fibrinogens","volume":"17","author":"A Clauss","year":"1957","journal-title":"Acta Haematol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1182\/blood.V71.1.220.220","article-title":"Measurement of plasminogen activator inhibitor 1 in biological fluids with a murine monoclonal antibodybased enzyme-linked immunoassay","volume":"71","author":"PJ De Clerck","year":"1988","journal-title":"Blood"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1055\/s-0038-1660097","article-title":"Assay of tissue plasminogen activator (t-PA) with an enzyme-linked immunosorbent assay (ELISA) based on three murine monoclonal antibodies to t-PA","volume":"54","author":"P Holvoet","year":"1985","journal-title":"Thromb Haemost"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0049-3848(88)90177-6","article-title":"Determination of the plasminogen activator inhibitor in plasma using t-PA and chromogenic single-point poly- D-Lysine stimulated assay","volume":"50","author":"E Eriksson","year":"1988","journal-title":"Thromb Res"},{"key":"ref37","first-page":"725","article-title":"Dosage du plasminog\u00e8ne \u00e0 l\u2019aide d\u2019un substrate chromog\u00e8ne tripeptidique","volume":"24","author":"C Soria","year":"1976","journal-title":"Pathol Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1055\/s-0038-1656116","article-title":"The origin of P-selectin as a circulating plasma protein","volume":"77","author":"R Fijnheer","year":"1997","journal-title":"Thromb Haemost"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00694339","article-title":"Pharmacokinetics of busulphan: correlation with veno-occlusive disease in patients undergoing bone marrow transplantation","volume":"25","author":"LB Grochow","year":"1989","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/BF00689702","article-title":"Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology","volume":"28","author":"M Hassan","year":"1991","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.bmt.1704069","article-title":"Incidence, survival and risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients","volume":"32","author":"CC Barker","year":"2003","journal-title":"Bone Marrow Transplant"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/sj.bmt.1703393","article-title":"Veno-occlusive disease of the liver in children with solid tumors undergoing autologous hematopoietic progenitor cell transplantation: a high incidence in patients with neuroblastoma","volume":"29","author":"B Horn","year":"2002","journal-title":"Bone Marrow Transplant"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3109\/10428199809092697","article-title":"Subclinical alterations in coagulation and fibrinolysis in patients undergoing autologous peripheral blood stem cell transplantation","volume":"28","author":"A Notoya","year":"1998","journal-title":"Leuk Lymphoma"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/mpo.10145","article-title":"Markers of endothelial function in pediatric stem cell transplantation for acute leukemia","volume":"40","author":"G Luzzatto","year":"2003","journal-title":"Med Pediatr Oncol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1084\/jem.163.5.1260","article-title":"Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells","volume":"163","author":"JJ Emeis","year":"1986","journal-title":"J Exp Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1097\/00007890-200005270-00026","article-title":"Improved fibrinolytic capacity after withdrawal of steroid immunosuppression in renal transplant recipients","volume":"69","author":"MT Sartori","year":"2000","journal-title":"Transplantation"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1046\/j.1538-7836.2003.00279.x","article-title":"Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk","volume":"1","author":"I Juhan-Vague","year":"2003","journal-title":"J Thromb Haemost"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00001721-199710000-00001","article-title":"Veno-occlusive disease of the liver after bone marrow transplantation: is hypercoagulability really part of the problem?","volume":"8","author":"W Korte","year":"1997","journal-title":"Blood Coag Fibrinol"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH04-09-0621.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T13:59:27Z","timestamp":1678802367000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH04-09-0621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":48,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,12,11]]},"published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1160\/th04-09-0621","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}