{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:01:52Z","timestamp":1791313312277,"version":"4.3.1"},"reference-count":94,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The intravascular maof nifestation Staphylococcus aureus infection is often associated with a severe, and sometimes catastrophic disease. Many host factors contribute to endothelial tropism of S.aureus including subendothelial matrix proteins,endothelial cell receptors, and platelets that are engaged together with S. aureus cell wall adhesins such as the fibronectin binding proteins. Recently, the role of secreted staphylococcal factors that were initially identified by virtue of their binding function with host proteins and ligands, has been reappraised in this regard. Among these, bacterial proteins without significant homology among each other, coagulase (Coa), the extracellular fibrinogen binding protein (Efb), the extracellular matrix binding protein (Emp), or the extracellular adhesive protein (Eap), are the most prominent ones to be associated with endovascular disease. Newly discovered interactions with host components may account for profound effects on immunmodulation and wound healing which are summarized in this short review and which ascribe an important role of these molecules in acute and chronic endo- and extravascular staphylococcal disease. Further research in the complex functional role of these \"secretable expanded repertoire adhesive molecules\" (SERAM) may not only help to increase our understanding in the pathogenesis of S. aureus infection but can specify novel targets for preventive or therapeutic strategies.<\/jats:p>","DOI":"10.1160\/th05-05-0306","type":"journal-article","created":{"date-parts":[[2005,7,14]],"date-time":"2005-07-14T13:52:10Z","timestamp":1121349130000},"page":"278-285","source":"Crossref","is-referenced-by-count":178,"title":["Staphylococcus aureus interactions with the endothelium"],"prefix":"10.1160","volume":"94","author":[{"given":"Triantafyllos","family":"Chavakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Wiechmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus T.","family":"Preissner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Medical progress \u2013 Staphylococcus aureus infections","volume":"339","author":"FD Lowy","year":"1998","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0891-5520(01)00003-4","article-title":"Staphylococcus aureus bacteremia and endocarditis","volume":"16","author":"CA Petti","year":"2002","journal-title":"Infect Dis Clin North Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1086\/427806","article-title":"Risk factors for hematogenous complications of intravscular catheter- associated Staphylococcus aureus bacteremia","volume":"40","author":"VG Fowler","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref4","first-page":"57","article-title":"Preventing postoperative Staphylococcus infections: an update","volume":"11","author":"M Grady","year":"2003","journal-title":"Surg Technol Int"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00001432-200404000-00004","article-title":"Bacteria and wound healing","volume":"17","author":"R Edwards","year":"2004","journal-title":"Curr Opin Infect Dis"},{"issue":"91","key":"ref6","first-page":"539","article-title":"Winning the battle but losing the war: methicillin-resistant Staphylococcus aureus (MRSA) infection at a teaching hospital","volume":"998","author":"M Farrington","journal-title":"Q J Med"},{"key":"ref7","first-page":"1730","article-title":"Community- adapated methicillin-resistant Staphylococcus aureus (MRSA): population dynamics of an expanding community reservoir of MRSA","volume":"15","author":"HA Carleton","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref8","first-page":"322","article-title":"Vancomycin-resistant Staphylococcus aureus \u2013 New York, 2004","volume":"53","year":"2004","journal-title":"MMWR"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0966-842X(98)01400-0","article-title":"Surface protein adhesins of Staphylococcus aureus","volume":"6","author":"TJ Foster","year":"1998","journal-title":"Trends Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"13863","DOI":"10.1074\/jbc.275.18.13863","article-title":"The fibronectin- binding MSCRAMM FnbpA of Staphylococcus aureus is a bifunctional protein that also binds to fibrinogen","volume":"275","author":"ER Wann","year":"2000","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2958.1994.tb00304.x","article-title":"Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus","volume":"11","author":"D McDevitt","year":"1994","journal-title":"Mol Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1365-2958.1998.01050.x","article-title":"Clumping factor B (ClfB), a new surface-located fibrinogenbinding adhesin of Staphylcoccus aureus","volume":"30","author":"D Ni Eidhin","year":"1998","journal-title":"Mol Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"29135","DOI":"10.1074\/jbc.273.44.29135","article-title":"Anchor structure of staphylococcal surface proteins II. COOHterminal structure of muramidase and amidase-solubilized surface protein","volume":"273","author":"WW Navarre","year":"1998","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.080520697","article-title":"Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections","volume":"97","author":"SK Mazmanian","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1099\/mic.0.25996-0","article-title":"Characterization of novel LPXTG-containing proteins of Staphylococcus lococcus aureus identified from genome sequences","volume":"149","author":"FM Roche","year":"2003","journal-title":"Microbiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1172\/JCI114560","article-title":"A human endothelial cell membrane protein that binds Staphylococcus aureus in vitro","volume":"85","author":"DC Tompkins","year":"1990","journal-title":"J Clin Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1128\/iai.60.3.965-969.1992","article-title":"Staphylococcus aureus proteins that bind to human endothelial cells","volume":"60","author":"DC Tompkins","year":"1992","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1128\/IAI.69.10.6296-6302.2001","article-title":"Reassessing the role of Staphylococcus aureus clumping factor and fibronectin-binding protein by expression in Lactococcus lactis","volume":"69","author":"YA Que","year":"2001","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study","volume":"29","author":"BF Stewart","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1086\/516502","article-title":"Interaction of von Willebrand factor with Staphylococcus aureus","volume":"176","author":"M Herrmann","year":"1997","journal-title":"J Infect Dis"},{"key":"ref21","first-page":"2149","article-title":"Protein A is the von Willebrand factor binding protein on Staphylococcus aureus","volume":"96","author":"J Hartleib","year":"2000","journal-title":"Blood"},{"key":"ref22","first-page":"87","volume-title":"Extracellular matrix and host cell surfaces: potential sites of pathogen interaction","author":"KT Preissner","year":"2005"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1086\/429692","article-title":"Lack of wall teichoic acids in Staphylococcus aureus leads to reduced interactions with endothelial cells and to attenuated virulence in a rabbit model of endocarditis","volume":"191","author":"C Weidenmaier","year":"2005","journal-title":"J Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1086\/427193","article-title":"Intravital fluorescence microscopy: a novel tool for the study of the interaction of Staphylococcus aureus with the microvascular endothelium in vivo","volume":"191","author":"MW Laschke","year":"2005","journal-title":"J Infect Dis"},{"key":"ref25","first-page":"367","article-title":"Platelet interaction with bacteria. I. Reaction phases and effects of inhibitors","volume":"65","author":"CC Clawson","year":"1971","journal-title":"Am J Pathol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/infdis\/167.2.312","article-title":"Adhesion of Staphylococcus aureus to surface-bound platelets: Role of fibrinogen\/fibrin and platelet integrins","volume":"167","author":"M Herrmann","year":"1993","journal-title":"J Infect Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1128\/IAI.69.5.3120-3127.2001","article-title":"Clumping factor A mediates binding of Staphylococcus aureus to human platelets","volume":"69","author":"IR Siboo","year":"2001","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1128\/IAI.68.4.2061-2068.2000","article-title":"Staphylococcus aureus protein A recognizes platelet gC1qR\/p33: a novel mechanism for staphylococcal in teractions with platelets","volume":"68","author":"T Nguyen","year":"2000","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1086\/341081","article-title":"Platelet- binding domains in 2 fibrinogen-binding proteins of Staphylococcus aureus identified by phage display","volume":"186","author":"C Heilmann","year":"2002","journal-title":"J Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1086\/421914","article-title":"Staphylococcus aureus fibronectin-binding protein (FnBP) mediates adherence to platelets and platelet aggregation","volume":"190","author":"C Heilmann","year":"2004","journal-title":"J Infect Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1128\/iai.63.9.3634-3641.1995","article-title":"Staphylococcus aureus induces platelet aggregation via a fibrinogen-dependent mechanism which is independent of principal platelet glycoprotein IIb\/IIIa fibrinogen- binding domains","volume":"63","author":"AS Bayer","year":"1995","journal-title":"Infect Immun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1046\/j.1365-2958.2002.02935.x","article-title":"Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A","volume":"44","author":"L O\u2019Brien","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/01.CIR.0000134486.93030.E7","article-title":"Soluble fibrin is the main mediator of S. aureus adhesion to platelets","volume":"110","author":"S Niemann","year":"2004","journal-title":"Circulation"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1128\/iai.65.8.3293-3299.1997","article-title":"Phenotypic resistance to thrombin-induced platelet microbicidal protein in vitro is correlated with enhanced virulence in experimental endocarditis due to Staphylococcus aureus","volume":"65","author":"VK Dhawan","year":"1997","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1086\/423145","article-title":"Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombininduced platelet microbicidal protein","volume":"190","author":"VG Fowler","year":"2004","journal-title":"J Infect Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1160\/TH05-04-0235","article-title":"Mechanism and consequences of invasion of endothelial cells by Staphylococcus aureus","volume":"94","author":"B Sinha","year":"2005","journal-title":"Thromb Haemost"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1128\/IAI.72.12.7155-7163.2004","article-title":"Truncation of fibronectin-binding proteins in Staphylococcus aureus strain Newman leads to deficient adherence and host cell invasion due to loss of the cell wall anchor function","volume":"72","author":"M Grundmeier","year":"2004","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/infdis\/173.3.739","article-title":"Staphylococcus aureus small colony variants are induced by the endothelial cell intracellular milieu","volume":"173","author":"O Vesga","year":"1996","journal-title":"J Infect Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1128\/iai.55.9.2155-2163.1987","article-title":"Ingestion of Staphylococcus aureus by bovine endothelial cells results in time- and inoculum-dependent damage to endothelial cell monolayers","volume":"55","author":"JM Vann","year":"1987","journal-title":"Infect Immun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","article-title":"Wound healing\u2014aiming for perfect skin regeneration","volume":"276","author":"P Martin","year":"1997","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"AJ Singer","year":"1999","journal-title":"N Engl J Med"},{"key":"ref42","first-page":"86","article-title":"The role of CXC chemokines in the regulation of angiogenesis","volume":"72","author":"MP Keane","year":"1999","journal-title":"Chem Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.immunol.18.1.217","article-title":"The biology of chemokines and their receptors","volume":"18","author":"D Rossi","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm","volume":"76","author":"TA Springer","year":"1994","journal-title":"Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0955-0674(97)80117-2","article-title":"Leukocyte adhesion. CD11\/CD18 integrins and intercellular adhesion molecules","volume":"9","author":"CG Gahmberg","year":"1997","journal-title":"Curr Opin Cell Biol."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"21785","DOI":"10.1074\/jbc.R000003200","article-title":"Ligand binding to integrins","volume":"275","author":"EF Plow","year":"2000","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1055\/s-0037-1613537","article-title":"Leukocyte trans-endothelial migration: JAMs add new pieces to the puzzle","volume":"89","author":"T Chavakis","year":"2003","journal-title":"Thromb Haemost"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1182\/blood.V84.7.2068.2068","article-title":"Leukocyte-endothelial adhesion molecules","volume":"84","author":"TM Carlos","year":"1994","journal-title":"Blood"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/iai.64.7.2804-2807.1996","article-title":"Role of intercellular adhesion molecule 1 in pathogenesis of staphylococcal arthritis and in host defense against staphylococcal bacteremia","volume":"64","author":"M Verdrengh","year":"1996","journal-title":"Infect Immun"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/infdis\/167.5.997","article-title":"Role of superantigens in human disease","volume":"167","author":"PM Schlievert","year":"1993","journal-title":"J Infect Dis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1126\/science.7997880","article-title":"Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1","volume":"266","author":"J Kim","year":"1994","journal-title":"Science"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1699-0463.1996.tb04955.x","article-title":"Bacterial colonization and healing of venous leg ulcers","volume":"104","author":"SM Madsen","year":"1996","journal-title":"APMIS"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1053\/ejvs.2001.1436","article-title":"Methicillin resistant Staphylococcus aureus in patients undergoing major amputation","volume":"22","author":"SA Grimble","year":"2001","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1128\/iai.60.4.1514-1523.1992","article-title":"Genetic evidence that bound coagulase of Staphylococcus aureus is not clumping factor","volume":"60","author":"D McDevitt","year":"1992","journal-title":"Infect Immun"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/IAI.69.2.657-664.2001","article-title":"Study of Staphylococcus aureus pathogenic genes by transfer and expression in the less virulent organism Streptococcus gordonii","volume":"69","author":"P Stutzmann Meier","year":"2001","journal-title":"Infect Immun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1128\/iai.63.5.1914-1920.1995","article-title":"Cloning, expression, and nucleotide sequence of Staphylococcus aureus gene (fbpA) encoding a fibrinogen- binding protein","volume":"63","author":"AL Cheung","year":"1995","journal-title":"Infect Immun"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1128\/JB.187.11.3698-3707.2005","article-title":"Structural comparison of ten serotypes of staphylocoagulases in Staphylococcus aureus","volume":"187","author":"S Watanabe","year":"2005","journal-title":"J Bacteriol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1099\/00221287-148-7-2037","article-title":"A novel von Willebrand factor binding protein expressed by Staphylococcus aureus","volume":"148","author":"J Bjerketorp","year":"2002","journal-title":"Microbiology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1574-6968.2004.tb09549.x","article-title":"The von Willebrand factor-binding protein (vWbp) of Staphylococcus aureus is a coagulase","volume":"234","author":"J Bjerketorp","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1128\/jcm.33.9.2347-2352.1995","article-title":"Incidence of the highly conserved fib gene and expression of the fibrinogen- binding (Fib) protein among clinical isolates of Staphylococcus aureus","volume":"33","author":"MK Boden Wastfelt","year":"1995","journal-title":"J Clin Microbiol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"31691","DOI":"10.1074\/jbc.M104554200","article-title":"Extracellular fibrinogen binding protein, Efb, from Staphy lococcus aureus blocks platelet aggregation due to its binding to the \u03b1-chain","volume":"276","author":"M Palma","year":"2001","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1006\/bbrc.1998.9028","article-title":"Identification of functional domains in Efb, a fibrinogen binding protein of Staphylococcus aureus","volume":"248","author":"D Wade","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"13177","DOI":"10.1074\/jbc.273.21.13177","article-title":"Multiple binding sites in the interaction between an extracellular fibrinogen- binding protein from Staphylococcus aureus and fibrinogen","volume":"273","author":"M Palma","year":"1998","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1128\/CDLI.7.1.14-20.2000","article-title":"Antibody responses in patients with staphylococcal septicemia against two Staphylococcus aureus fibrinogen binding proteins: clumping factor and an extracellular fibrinogen binding protein","volume":"7","author":"P Colque-Navarro","year":"2000","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1128\/iai.64.12.5284-5289.1996","article-title":"Lack of the extracellular 19-kilodalton fibrinogen-binding protein from Staphylococcus aureus decreases virulence in experimental wound infection","volume":"64","author":"M Palma","year":"1996","journal-title":"Infect Immun"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1160\/TH03-05-0287","article-title":"Extracellular fibrinogen binding protein, Efb, from Staphylococcus aureus binds to platelets and inhibits platelet aggregation","volume":"91","author":"O Shannon","year":"2004","journal-title":"Thromb Haemost"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"50710","DOI":"10.1074\/jbc.M408570200","article-title":"Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen binding protein (Efb)","volume":"279","author":"LY Lee","year":"2004","journal-title":"J Biol Chem"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1086\/422259","article-title":"Inhibition of complement activation by a secreted Staphylococcus aureus protein","volume":"190","author":"LY Lee","year":"2004","journal-title":"J Infect Dis"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"6778","DOI":"10.1128\/JB.183.23.6778-6786.2001","article-title":"Identification and characterization of a novel 38,5-kilodalton secretory protein of Staphylococcus aureus with extended- spectrum binding activitiy for extracellular matrix and plasma","volume":"183","author":"M Hussain","year":"2001","journal-title":"J Bacteriol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1128\/iai.61.6.2479-2485.1993","article-title":"Identification of a Staphylococcus aureus extracellular matrix- binding protein with broad specificity","volume":"61","author":"MH McGavin","year":"1993","journal-title":"Infect Immun"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"21457","DOI":"10.1074\/jbc.270.37.21457","article-title":"Staphylococcus aureus expresses a major histocompatibility complex class II analog","volume":"270","author":"K J\u00f6nsson","year":"1995","journal-title":"J Biol Chem"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1099\/mic.0.26465-0","article-title":"The adhesive and immunomodulating properties of the multifunctional Staphylococcus aureus protein Eap","volume":"149","author":"N Harraghy","year":"2003","journal-title":"Microbiology"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1128\/JB.181.9.2840-2845.1999","article-title":"Adherence of Staphylococcus aureus is enhanced by an endogenous secreted protein with broad binding activity","volume":"181","author":"M Palma","year":"1999","journal-title":"J Bacteriol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/CDLI.8.6.1271-1276.2001","article-title":"Analogs of the extracellular adherence protein (Eap) are conserved and prevalent in clinical Staphylococcus aureus isolates","volume":"8","author":"M Hussain","year":"2001","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1128\/IAI.70.6.2933-2940.2002","article-title":"Insertional inactivation of Eap in Staphylococcus aureus strain Newman confers reduced staphylococcal binding to fibroblasts","volume":"70","author":"M Hussain","year":"2002","journal-title":"Infect Immun"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1128\/IAI.71.5.2310-2317.2003","article-title":"Extracellular adherence protein from Staphylococcus aureus enhances internalization into eukaryotic cells","volume":"71","author":"A Haggar","year":"2003","journal-title":"Infect Immun"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1078\/1438-4221-00212","article-title":"The role of the map protein in Staphylococcus aureus matrix protein and eukaryotic cell adherence","volume":"292","author":"B Kreikemeyer","year":"2002","journal-title":"Int J Med Microbiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nm728","article-title":"Staphylococcus aureus extracellular adherence protein serves as anti- inflammatory factor by inhibiting the recruitment of host leukocytes","volume":"8","author":"T Chavakis","year":"2002","journal-title":"Nat Med"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1172\/JCI0216318","article-title":"The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses","volume":"110","author":"LY Lee","year":"2002","journal-title":"J Clin Invest"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1099\/mic.0.27902-0","article-title":"Sae is essential for expression of the staphylococcal adhesins Eap and Emp","volume":"151","author":"N Harraghy","year":"2005","journal-title":"Microbiology"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1128\/JB.185.21.6278-6286.2003","article-title":"Molecular architecture of the regulatory locus sae of Staphylococcus aureus and its impact on expression of virulence factors","volume":"185","author":"A Steinhuber","year":"2003","journal-title":"J Bacteriol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1099\/mic.0.26575-0","article-title":"The staphyloccal saeRS system coordinates environmental signals with agr quorum sensing","volume":"149","author":"RP Novick","year":"2003","journal-title":"Microbiology"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"17243","DOI":"10.1074\/jbc.M412311200","article-title":"The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens","volume":"280","author":"BV Geisbrecht","year":"2005","journal-title":"J Biol Chem"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1128\/JB.183.13.3999-4003.2001","article-title":"Rebinding of extracellular adherence protein eap to Staphylococcus aureus can occur through a surface-bound neutral phosphatase","volume":"183","author":"M Flock","year":"2001","journal-title":"J Bacteriol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2249.1995.tb03714.x","article-title":"Two novel cationic staphylococcal proteins induce IL-2 secretion, proliferation and immunoglobulin synthesis in peripheral blood mononuclear cells (PBMC) of both healthy controls and patients with common variable immunodeficiency (CVID)","volume":"100","author":"A Jahreis","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1046\/j.1365-2133.2000.03412.x","article-title":"Effects of two novel cationic staphylococcal proteins (NP-tase and p70)and enterotoxin B on IgE synthesis and interleukin- 4 and interferon-gamma production in patients with atopic dermatitis","volume":"142","author":"A Jahreis","year":"2000","journal-title":"Br J Dermatol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1084\/jem.20031636","article-title":"Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent","volume":"199","author":"CJC de Haas","year":"2004","journal-title":"J Exp Med"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.4049\/jimmunol.172.11.6994","article-title":"Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor","volume":"172","author":"B Postma","year":"2004","journal-title":"J Immunol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1172\/JCI0215755","article-title":"Role of matrix metalloproteinase- 9 in angiogenesis caused by ocular infection with herpes simplex virus","volume":"110","author":"S Lee","year":"2002","journal-title":"J Clin Invest"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/cyto.1997.0297","article-title":"Activated human neutrophils express vascular endothelial growth factor (VEGF)","volume":"10","author":"NJ Webb","year":"1998","journal-title":"Cytokine"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1160\/TH03-04-0213","article-title":"The functional role of blood platelet components in angiogenesis","volume":"92","author":"JS Rhee","year":"2004","journal-title":"Thromb Haemost"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1172\/JCI200423083","article-title":"Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus","volume":"114","author":"DC Melles","year":"2004","journal-title":"J Clin Invest"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1172\/JCI200423825","article-title":"The Staphylococcus aureus \u2018\u2018superbug\u2019\u2019","volume":"114","author":"TJ Foster","year":"2004","journal-title":"J Clin Invest"},{"key":"ref95","first-page":"223","article-title":"MSCRAMM\u2013 targeted vaccines and immunotherapy for staphylococcal infection","volume":"7","author":"JM Rivas","year":"2004","journal-title":"Curr Opin Drug Discov Devel"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH05-05-0306.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T11:52:30Z","timestamp":1685533950000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH05-05-0306"}},"subtitle":["The role of bacterial \u201cSecretable Expanded Repertoire Adhesive Molecules\u201d (SERAM) in disturbing host defense systems"],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":94,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2017,12,5]]},"published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1160\/th05-05-0306","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}