{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:48:21Z","timestamp":1790966901805,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"\u00c5ke Wiberg, Alfred \u00d6sterlund"},{"DOI":"10.13039\/501100001729","name":"Swedish Foundation for Strategic Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Royal Physiographical Society in Lund, the Medical Faculty of Lund University, the Swedish Research Council","award":["project 13413"],"award-info":[{"award-number":["project 13413"]}]},{"name":"Blood and Defence Network at Lund University, and Hansa Medical AB"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\nStreptococcus pyogenes is an important Gram-positive pathogen that is strictly limited to infections in humans. Here we report that streptolysin O (SLO),a cytolytic exotoxin secreted by S. pyogenes, activates human polymorphonuclear neutrophils (PMNs) by perforating these cells. This appears to be followed by an influx of Ca2+ and p38 MAPK activation. As a consequence, PMNs secrete heparin-binding protein, a potent inducer of vascular leakage, and neutrophil-borne proteins, including LL-37, \u03b1-defensins, and elastase. The results of the present work therefore suggest that the interaction between SLO and PMNs evokes an exaggerated host response which may contribute to the pathogenesis of local and generalized S. pyogenes infections.<\/jats:p>","DOI":"10.1160\/th05-08-0572","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T11:37:01Z","timestamp":1147779421000},"page":"982-990","source":"Crossref","is-referenced-by-count":39,"title":["Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators"],"prefix":"10.1160","volume":"95","author":[{"given":"Maria","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"S\u00f8rensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00f6rgelin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Weineisen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Sj\u00f6bring","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Herwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,30]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH05-08-0572.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T02:43:22Z","timestamp":1521600202000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH05-08-0572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2017,11,30]]},"published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.1160\/th05-08-0572","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}