{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T16:34:06Z","timestamp":1649954046529},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"\u201cmedizinischwissenschaftlichen Fonds des Buergermeisters der Bundeshauptstadt Wien\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Interferon alpha (IFN-\u03b1) is used to treat haematological and solid malignancies and is the gold standard therapy for chronic hepatitisC infection in combination with ribavirin. It has a well known platelet lowering effect and was recently shown to impair platelet aggregation in the presence of various agonists and has been accused to increase patients\u2019 bleeding risk during IFN-\u03b1 therapy. Thus, we hypothesised that antiviral treatment decreases GpIIb\/IIIa activation and affects global platelet function. In a prospective clinical trial, we examined the effects of combination therapy with pegylated IFN-\u03b1 2a (PegIFN-\u03b1 2a) and ribavirin on platelet GpIIb\/IIIa activation and platelet secretion in 20 patients with chronic hepatitis C at week 2, 4, 8 and 12 after the beginning of therapy. In addition, we determined global platelet function (CEPI-CT) with the PFA-100 and vWF-Ag levels. Antiviral therapy significantly decreased GpIIb\/IIIa activation in a time dependent manner, whereas markers of platelet secretion (P-selectin, \u03b2-thromboglobulin) remained unchanged. Despite a marked elevation of vWF-Ag levels, CEPI-CT did not change compared to baseline levels. Antiviral therapy significantly decreases GpIIb\/IIIa activation in patients with chronic hepatitis C, while vWG-Antigen levels are markedly increased and \u03b1-granule secretion is not affected. This does not result in an alteration of global platelet function as assessed by the PFA-100, because elevated vWF-Antigen levels might compensate for the acquired defect.<\/jats:p>","DOI":"10.1160\/th05-12-0781","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T14:14:39Z","timestamp":1137680079000},"page":"260-266","source":"Crossref","is-referenced-by-count":4,"title":["Antiviral therapy decreases GpIIb\/IIIa activation of platelets in patients with chronic hepatitis C"],"prefix":"10.1160","volume":"95","author":[{"given":"Wolfgang","family":"Sieghart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Homoncik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Jilma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Formann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ferenci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Gangl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Peck-Radosavljevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,28]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH05-12-0781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T20:34:56Z","timestamp":1540413296000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH05-12-0781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2017,12,15]]},"published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.1160\/th05-12-0781","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}