{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:03:04Z","timestamp":1792803784060,"version":"4.5.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"Th\u00e9ramex"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Use of oral contraceptives (OC) that combine a progestogen with synthetic ethinyl estradiol (EE) is associated with increased risk of venous thromboembolism. NOMAC\/E2 is a new monophasic OC that combines nomegestrol acetate (NOMAC), a highly selective progestogen, with 17\u03b2-estradiol (E2). The study objective was to compare the effects on markers of haemostasis of NOMAC\/E2 (2.5 mg\/1.5 mg) versus the second-generation OC, levonorgestrel (LNG)\/EE (100 \u03bcg\/20 \u03bcg). Healthy women (age 18\u201338 years) received once-daily treatment for three consecutive 28-day cycles in a double-blind, randomised study: either NOMAC\/E2 for 24 days with a four-day placebo interval (n=45) or LNG\/ EE for 21 days with a seven-day placebo interval (n=45) per cycle. Mean changes from baseline to end-of-treatment in coagulation markers, including prothrombin fragment 1+2 (primary endpoint), fibrinolysis markers and platelet functions were assessed. Mean prothrombin fragment 1+2 levels (primary endpoint) did not increase with NOMAC\/E2 compared with LNG\/EE ( \u20130.02 vs. +0.08 nM, p&lt;0.01). Other significant differences between NOMAC\/E2 and LNG\/EE were mean changes in antithrombin (+0.3% vs. \u20134.4%, p&lt;0.001), activated protein C resistance \u2013 normalised ratio (+0.20 vs. +0.46, p&lt;0.01), D-dimer ( \u201353 vs. +43 ng\/ml, p&lt;0.001), plasminogen (+6% vs. +30%, p&lt;0.0001) and plasminogen activator inhibitor-1 ( \u20133.1 vs. \u20138.0 ng\/ml, p&lt;0.001). There was no effect of either treatment on platelet aggregation. The NOMAC\/E2 pill regimen has fewer adverse effects on blood biological coagulation and fibrinolysis markers than LNG\/EE. This suggests that NOMAC\/E2 could have a more favourable venous thromboembolism risk profile than LNG\/EE; further epidemiological data are required to confirm this.<\/jats:p>","DOI":"10.1160\/th10-05-0327","type":"journal-article","created":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T07:50:39Z","timestamp":1294818639000},"page":"560-567","source":"Crossref","is-referenced-by-count":88,"title":["Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate\/17\u03b2-estradiol, compared with those of levonorgestrel\/ethinyl estradiol"],"prefix":"10.1160","volume":"105","author":[{"given":"Martine","family":"Alhenc-Gelas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christilla","family":"Bachelot-Loza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Remones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"Dali Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Aiach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Scarabin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Gaussem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,27]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH10-05-0327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T07:59:30Z","timestamp":1521705570000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH10-05-0327"}},"subtitle":["A double-blind, randomised study"],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2017,11,24]]},"published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1160\/th10-05-0327","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}