{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:33:36Z","timestamp":1768779216735,"version":"3.49.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to assess the efficacy of Wilate\u00ae, a new generation, plasma-derived, high-purity, double virus-inactivated von Willebrand factor (VWF) and factor VIII (FVIII) concentrate (ratio close to physiological 1:1) in the perioperative management of haemostasis in von Willebrand disease (VWD). Data for VWD patients who received Wilate\u00ae for perioperative management were obtained from four European, prospective, open-label, non-controlled, non-randomised, multicentre phase II or III clinical trials. A total of 57 surgical procedures were performed (major: n = 27; minor n = 30) in 32 patients. The majority of patients (n = 19, 59.4%) had type 3 VWD, 9 (28.1%) had type 2 VWD and four (12.5%) had type 1 VWD. During major surgery, median daily FVIII dose and mean number of infusions were 25 IU\u2022kg-1 FVIII (VWF:RC\u00f423 IU\u2022kg-1) and 11.0, respectively. Corresponding values for minor surgery were 35 IU\u2022kg-1 (VWF:RCo ~32 IU\u2022kg-1) and 1.5. The efficacy of Wilate\u00ae was rated by the investigator as excellent or good in 51 of 53 (96%) procedures. Tolerability was rated as very good or good in 100% of major surgeries (27 of 27) and minor surgeries (29 of 29). Wilate\u00ae is an effective and well-tolerated VWF\/FVIII replacement therapy in the perioperative management of haemostasis in patients with VWD. It can be administered at a similar FVIII dose, but at a lower VWF dose, as compared to older generation products. Clinical benefits were shown in a population with a high proportion of type 3 VWD patients.<\/jats:p>","DOI":"10.1160\/th10-10-0631","type":"journal-article","created":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T09:07:20Z","timestamp":1301044040000},"page":"1072-1079","source":"Crossref","is-referenced-by-count":45,"title":["Efficacy and safety of a new generation von Willebrand factor\/factor VIII concentrate (Wilate\u00ae) in the management of perioperative haemostasis in von Willebrand disease patients undergoing surgery"],"prefix":"10.1160","volume":"105","author":[{"given":"Mario von","family":"Depka-Prondzinski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Windyga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the European Wilate\u00ae Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"10.1160\/TH10-10-0631-1","first-page":"94","volume":"88","author":"Castaman","year":"2003","journal-title":"Haematologica"},{"key":"10.1160\/TH10-10-0631-2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02146.x"},{"key":"10.1160\/TH10-10-0631-3","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000167656.77520.bb"},{"key":"10.1160\/TH10-10-0631-4","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000167658.85143.49"},{"key":"10.1160\/TH10-10-0631-5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01643.x"},{"key":"10.1160\/TH10-10-0631-6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-949667"},{"key":"10.1160\/TH10-10-0631-7","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.01.021"},{"key":"10.1160\/TH10-10-0631-8","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1182\/blood.V72.5.1449.1449","volume":"72","author":"Mannucci","year":"1988","journal-title":"Blood"},{"key":"10.1160\/TH10-10-0631-9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2005.11.010"},{"key":"10.1160\/TH10-10-0631-10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01901.x"},{"key":"10.1160\/TH10-10-0631-11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1055\/s-0037-1613022","volume":"87","author":"Lillicrap","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH10-10-0631-12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040403"},{"key":"10.1160\/TH10-10-0631-13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2003.00809.x"},{"key":"10.1160\/TH10-10-0631-14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02588.x"},{"key":"10.1160\/TH10-10-0631-15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01616.x"},{"key":"10.1160\/TH10-10-0631-16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01784.x"},{"key":"10.1160\/TH10-10-0631-17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90166-3"},{"key":"10.1160\/TH10-10-0631-18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0037-1613747","volume":"83","author":"Kraaijenhagen","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH10-10-0631-19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430702"},{"key":"10.1160\/TH10-10-0631-20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.01033.x"},{"key":"10.1160\/TH10-10-0631-21","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.2.450"},{"key":"10.1160\/TH10-10-0631-22","unstructured":"Pock K, Stadler M, Gruber G, et al. Product features of novel generation VWF\/FVIII concentrate in a comparison with first generation products. 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