{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:26:30Z","timestamp":1791588390516,"version":"4.3.4"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The pharmacokinetic (PK) profiles of von Willebrand factor (VWF) \/factor VIII (FVIII) concentrates are important for treatment efficacy and safety of von Willebrand disease (VWD) patients. This prospective, head-to-head, randomised crossover study compared the PK profile of a new, high purity, human plasma-derived (pd)VWF\/FVIII concentrate, Wilate\u00ae, with the PK profile of an intermediate purity (pd)VWF\/FVIII concentrate, Humate-P\u00af, in VWD patients. Subjects with inherited VWD were randomised to a single intravenous dose (40 IU\/kg VWF ristocetin cofactor activity [VWF:RCo]) of Wilate\u00ae or Humate-P\u00af in Period 1, and switched to the other study drug in Period 2. Each period was preceded by a washout time of \u22657 days. Coagulation factor parameters were analysed at multiple time-points. Of 22 randomised subjects, 20 had evaluable PK profiles, which indicated comparability for VWF antigen and VWF:RCo between Wilate\u00ae and Humate-P\u00af. The reported VWF:RCo average and terminal t1\/2 of 10.4 and 15.8 hours (h), respectively, for Wilate\u00ae and 9.3 h and 12.8 h for Humate-P\u00ae, were not statistically different. Also, the mean VWF:RCo in vivo recoveries (Wilate\u00ae 1.89, Humate-P\u00ae 1.99 IU\/dl per IU\/kg) were similar between the two replacement therapies. Wilate\u00ae showed parallel decay curves for VWF:RCo and FVIII clotting activity (FVIII:C) over time, while FVIII:C of Humate-P\u00ae displayed a plateau between 0 and 12\u201324 h. This study demonstrated bioequivalent PK properties for VWF between Wilate\u00ae and Humate-P\u00ae. The PK profile of Wilate\u00ae, combined with the 1:1 VWF\/FVIII ratio, theoretically should facilitate dosing and laboratory monitoring of VWF replacement to prevent bleeding in individuals with VWD.<\/jats:p>","DOI":"10.1160\/th11-02-0057","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T14:52:35Z","timestamp":1309791155000},"page":"279-288","source":"Crossref","is-referenced-by-count":26,"title":["The pharmacokinetic diversity of two von Willebrand factor (VWF)\/ factor VIII (FVIII) concentrates in subjects with congenital von Willebrand disease"],"prefix":"10.1160","volume":"106","author":[{"given":"Craig M.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedman","family":"Ken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce 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