{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:11:19Z","timestamp":1791357079386,"version":"4.3.1"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A nation-wide cross-sectional study was initiated to assess gynaecological and obstetrical symptoms in an unselected cohort of women with moderate and severe von Willebrand disease (VWD) in the Netherlands. A total of 423 women aged \u226516 years were included. Bleeding severity was measured using the Tosetto Bleeding Score (BS). Menorrhagia, defined as occurrence of \u22652 menorrhagia symptoms, was reported by 81%. Of all VWD women, 78% received any kind of treatment for menorrhagia and 20% underwent a hysterectomy predominantly because of severe menstrual bleeding. Over half of the women reported more blood loss than can be expected with a normal delivery. In 52% of reported pregnancy losses curettage was needed because of bleeding. Mean number of live births was 1.9, which is comparable with the general Dutch population. In conclusion, women with moderate or severe VWD frequently have menorrhagia in need of treatment, and 20% of the VWD women underwent a hysterectomy. Bleeding complications occurred in over 50% of the women after childbirth or pregnancy loss. Progeny seems not to be affected in women with moderate or severe VWD.<\/jats:p>","DOI":"10.1160\/th11-03-0180","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T12:44:36Z","timestamp":1316695476000},"page":"885-892","source":"Crossref","is-referenced-by-count":91,"title":["Gynaecological and obstetric bleeding in moderate and severe von Willebrand disease"],"prefix":"10.1160","volume":"106","author":[{"given":"Eva","family":"de Wee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Knol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Mauser-Bunschoten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"van der Bom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Eikenboom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Fijnvandraat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arja de","family":"Goede-Bolder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Laros-van Gorkom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ypma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Zweegman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Meijer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Leebeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the WiN study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"10.1160\/TH11-03-0180-1","first-page":"1","volume":"238","author":"Silwer","year":"1973","journal-title":"Acta Paed Scand"},{"key":"10.1160\/TH11-03-0180-2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01847.x"},{"key":"10.1160\/TH11-03-0180-3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.00208.x"},{"key":"10.1160\/TH11-03-0180-4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00447.x"},{"key":"10.1160\/TH11-03-0180-5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00342.x"},{"key":"10.1160\/TH11-03-0180-6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2003.00832.x"},{"key":"10.1160\/TH11-03-0180-7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1160\/TH07-06-0419","volume":"99","author":"Lethagen","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH11-03-0180-8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00285.x"},{"key":"10.1160\/TH11-03-0180-9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00756.x"},{"key":"10.1160\/TH11-03-0180-10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02146.x"},{"key":"10.1160\/TH11-03-0180-11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01643.x"},{"key":"10.1160\/TH11-03-0180-12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00991.x"},{"key":"10.1160\/TH11-03-0180-13","doi-asserted-by":"crossref","unstructured":"James AH, Kouides PA, Abdul-Kadir R, et al. 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