{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:55:16Z","timestamp":1762458916782},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Lack of effective treatment for menorrhagia is the greatest unmet healthcare need in women with von Willebrand disease (VWD). We conducted a single-centre phase II clinical trial to determine efficacy and safety of recombinant IL-11 (rhIL-11, Neumega\u00ae) given subcutaneously for up to seven days during six consecutive menstrual cycles each in seven women with mild VWD and menorrhagia refractory to haemostatic or hormonal agents. rhIL-11 reduced menstrual bleeding severity as measured by pictorial blood assessment chart (PBAC) \u226550% (to &lt;100) in 71% of subjects, cycle severity \u226550% in 71%, and bleeding duration \u22652 days in 85%, all p\u22640.01. After rhIL-11, plasma VWF:RCo increased 1.1-fold, but did not correlate with PBAC, r=0.116, bleeding duration, r=0.318, or cycle severity, r=-0.295, or hsCRP, r=-0.003, all p&gt;0.05. Platelet VWF mRNA expression by quantitative PCR increased mean four-fold (1.0\u201313.5). rhIL-11 was well tolerated with grade 1 or less fluid retention, flushing, conjunctival erythema, and local bruising. In summary, rhIL-11 reduces menorrhagia safely and warrants further study.<\/jats:p>","DOI":"10.1160\/th11-04-0274","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T12:20:47Z","timestamp":1313065247000},"page":"641-645","source":"Crossref","is-referenced-by-count":17,"title":["Phase II prospective open-label trial of recombinant interleukin-11 in women with mild von Willebrand disease and refractory menorrhagia"],"prefix":"10.1160","volume":"106","author":[{"given":"Rachel","family":"Jankowitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Jaworski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Merricks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Kloos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Nichols","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Ragni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"10.1160\/TH11-04-0274-1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00342.x"},{"key":"10.1160\/TH11-04-0274-2","doi-asserted-by":"crossref","unstructured":"James A, Ragni MV, Picozzi V. ASH Special Educational Symposium: Bleeding Disorders in Premenopausal Women: Another Public Health Crisis for Hematology. Hematology 2006; 474-485.","DOI":"10.1182\/asheducation-2006.1.474"},{"key":"10.1160\/TH11-04-0274-3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02494.x"},{"key":"10.1160\/TH11-04-0274-4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-949665"},{"key":"10.1160\/TH11-04-0274-5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02269.x"},{"key":"10.1160\/TH11-04-0274-6","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1182\/blood.V90.7.2515","volume":"90","author":"Mannucci","year":"1997","journal-title":"Blood"},{"key":"10.1160\/TH11-04-0274-7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01663.x"},{"key":"10.1160\/TH11-04-0274-8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00678.x"},{"key":"10.1160\/TH11-04-0274-9","unstructured":"Byams VR, Baker J, Brown DL, et al. Baseline characteristics of females with bleeding disorders receiving care in the U.S. HTC Network. National Conf on Blood Disorders in Public Health 2010; 77: E3. Abstract 4."},{"key":"10.1160\/TH11-04-0274-10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07610.x"},{"key":"10.1160\/TH11-04-0274-11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01643.x"},{"key":"10.1160\/TH11-04-0274-12","first-page":"3","volume":"17","author":"","year":"2003","journal-title":"In Healthy People 2010: A Systematic Approach to Health Improvement."},{"key":"10.1160\/TH11-04-0274-13","first-page":"3607","volume":"87","author":"Tepler","year":"1996","journal-title":"Blood"},{"key":"10.1160\/TH11-04-0274-14","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1182\/blood.V87.9.3615.bloodjournal8793615","volume":"87","author":"Gordon","year":"1996","journal-title":"Blood"},{"key":"10.1160\/TH11-04-0274-15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01827.x"},{"key":"10.1160\/TH11-04-0274-16","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00062-V"},{"key":"10.1160\/TH11-04-0274-17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0464"},{"key":"10.1160\/TH11-04-0274-18","first-page":"420","volume":"119","author":"Benson","year":"1992","journal-title":"J Lab Clin Med"},{"key":"10.1160\/TH11-04-0274-19","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.12.3055"},{"key":"10.1160\/TH11-04-0274-20","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1182\/blood.V81.10.2644.2644","volume":"81","author":"Nichols","year":"1993","journal-title":"Blood"},{"key":"10.1160\/TH11-04-0274-21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2937"},{"key":"10.1160\/TH11-04-0274-22","unstructured":"National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 4.03, June 14, 2010; Available at: http:\/\/ctep.cancer.gov\/forms\/CTCAEv4.pdf."},{"key":"10.1160\/TH11-04-0274-23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430702"},{"key":"10.1160\/TH11-04-0274-24","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200309000-00012"},{"key":"10.1160\/TH11-04-0274-25","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1160\/TH-09-02-0104","volume":"102","author":"Luxembourg","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH11-04-0274-26","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.05.029"},{"key":"10.1160\/TH11-04-0274-27","unstructured":"Ragni MV, Kessler CM. Hemophilia and Von Willebrand Disease Subcommittee: Four Randomized Controlled Clinical Trial Concepts. State of the Science Symposium in Transfusion Medicine, Hemostasis and Thrombosis (SoS-TMH), NHLBI, Bethesda MD, September 14, 2009."}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH11-04-0274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T06:08:34Z","timestamp":1592806114000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH11-04-0274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":27,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,11,29]]},"published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1160\/th11-04-0274","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}