{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:27:53Z","timestamp":1791311273612,"version":"4.3.1"},"reference-count":121,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Neutrophils, as part of the innate immune system, are classically described to be main actors during the onset of inflammation enforcing rapid neutralisation and clearance of pathogens. Besides their wellstudied role in acute inflammatory processes, recent advances strongly indicate a so far underappreciated importance of neutrophils in initiation and development of atherosclerosis. This review focuses on current findings on the role of neutrophils in atherosclerosis. As pro-inflammatory mechanisms of neutrophils have primarily been studied in the microvascular environment; we here aim at translating these into the context of macrovascular inflammation in atherosclerosis. Since much of the pro-inflammatory activities of neutrophils stem from instructing neighbouring cell types, we highlight the promiscuous interplay between neutrophils and platelets, monocytes, T lymphocytes, and dendritic cells and its possible relevance to atherosclerosis.<\/jats:p>","DOI":"10.1160\/th11-07-0501","type":"journal-article","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T11:07:31Z","timestamp":1319108851000},"page":"839-848","source":"Crossref","is-referenced-by-count":54,"title":["Neutrophilic granulocytes \u2013 promiscuous accelerators of atherosclerosis"],"prefix":"10.1160","volume":"106","author":[{"given":"Yvonne","family":"D\u00f6ring","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco","family":"Megens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Soehnlein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maik","family":"Drechsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"10.1160\/TH11-07-0501-1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70266-8"},{"key":"10.1160\/TH11-07-0501-2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2001"},{"key":"10.1160\/TH11-07-0501-3","doi-asserted-by":"publisher","DOI":"10.1038\/nri2415"},{"key":"10.1160\/TH11-07-0501-4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.961714"},{"key":"10.1160\/TH11-07-0501-5","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090480"},{"key":"10.1160\/TH11-07-0501-6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.160697"},{"key":"10.1160\/TH11-07-0501-7","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.209296"},{"key":"10.1160\/TH11-07-0501-8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.985523"},{"key":"10.1160\/TH11-07-0501-9","doi-asserted-by":"publisher","DOI":"10.1038\/nri2779"},{"key":"10.1160\/TH11-07-0501-10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000071555","volume":"83","author":"Galligan","year":"2003","journal-title":"Chem Immunol Allergy"},{"key":"10.1160\/TH11-07-0501-11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/ATVBAHA.107.154807","volume":"28","author":"van","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1160\/TH11-07-0501-12","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200701000-00003"},{"key":"10.1160\/TH11-07-0501-13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000136335","volume":"15","author":"Kantari","year":"2008","journal-title":"Contrib Microbiol"},{"key":"10.1160\/TH11-07-0501-14","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1182\/blood.V81.11.2844.2844","volume":"81","author":"Ogawa","year":"1993","journal-title":"Blood"},{"key":"10.1160\/TH11-07-0501-15","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80504-X"},{"key":"10.1160\/TH11-07-0501-16","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1182\/blood.V84.6.1737.1737","volume":"84","author":"Lieschke","year":"1994","journal-title":"Blood"},{"key":"10.1160\/TH11-07-0501-17","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/oxfordjournals.aje.a009123","volume":"145","author":"Sweetnam","year":"1997","journal-title":"Am J Epidemiol"},{"key":"10.1160\/TH11-07-0501-18","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90384-1"},{"key":"10.1160\/TH11-07-0501-19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1189731"},{"key":"10.1160\/TH11-07-0501-20","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536053"},{"key":"10.1160\/TH11-07-0501-21","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00263-2"},{"key":"10.1160\/TH11-07-0501-22","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000134294.54422.2e"},{"key":"10.1160\/TH11-07-0501-23","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0210112"},{"key":"10.1160\/TH11-07-0501-24","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.01.011"},{"key":"10.1160\/TH11-07-0501-25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0272"},{"key":"10.1160\/TH11-07-0501-26","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2083"},{"key":"10.1160\/TH11-07-0501-27","doi-asserted-by":"publisher","DOI":"10.1038\/nm1551"},{"key":"10.1160\/TH11-07-0501-28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2593"},{"key":"10.1160\/TH11-07-0501-29","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00070-4"},{"key":"10.1160\/TH11-07-0501-30","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.4049\/jimmunol.181.8.5183","volume":"181","author":"von","year":"2008","journal-title":"J Immunol"},{"key":"10.1160\/TH11-07-0501-31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.924886"},{"key":"10.1160\/TH11-07-0501-32","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"10.1160\/TH11-07-0501-33","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.161174"},{"key":"10.1160\/TH11-07-0501-34","doi-asserted-by":"publisher","DOI":"10.1038\/nri2096"},{"key":"10.1160\/TH11-07-0501-35","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0141-z"},{"key":"10.1160\/TH11-07-0501-36","first-page":"952","volume":"144","author":"Johnson-Tidey","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1160\/TH11-07-0501-37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119231"},{"key":"10.1160\/TH11-07-0501-38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3001"},{"key":"10.1160\/TH11-07-0501-39","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0537com"},{"key":"10.1160\/TH11-07-0501-40","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114111"},{"key":"10.1160\/TH11-07-0501-41","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4942"},{"key":"10.1160\/TH11-07-0501-42","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.8.1517"},{"key":"10.1160\/TH11-07-0501-43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.1.189"},{"key":"10.1160\/TH11-07-0501-44","doi-asserted-by":"crossref","first-page":"553","DOI":"10.4049\/jimmunol.163.2.553","volume":"163","author":"Ozaki","year":"1999","journal-title":"J Immunol"},{"key":"10.1160\/TH11-07-0501-45","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1096\/fj.05-4196fje","volume":"19","author":"Keiper","year":"2005","journal-title":"FASEB J"},{"key":"10.1160\/TH11-07-0501-46","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-188375"},{"key":"10.1160\/TH11-07-0501-47","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-047431"},{"key":"10.1160\/TH11-07-0501-48","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2062"},{"key":"10.1160\/TH11-07-0501-49","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000110503.16605.15"},{"key":"10.1160\/TH11-07-0501-50","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.08.012"},{"key":"10.1160\/TH11-07-0501-51","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi339"},{"key":"10.1160\/TH11-07-0501-52","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-156083"},{"key":"10.1160\/TH11-07-0501-53","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(00)00111-X"},{"key":"10.1160\/TH11-07-0501-54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00965.x"},{"key":"10.1160\/TH11-07-0501-55","doi-asserted-by":"publisher","DOI":"10.1038\/nature10146"},{"key":"10.1160\/TH11-07-0501-56","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.06.006"},{"key":"10.1160\/TH11-07-0501-57","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.07.007"},{"key":"10.1160\/TH11-07-0501-58","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.07.004"},{"key":"10.1160\/TH11-07-0501-59","doi-asserted-by":"publisher","DOI":"10.1038\/nm1565"},{"key":"10.1160\/TH11-07-0501-60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29499"},{"key":"10.1160\/TH11-07-0501-61","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01086.2009"},{"key":"10.1160\/TH11-07-0501-62","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.10.009"},{"key":"10.1160\/TH11-07-0501-63","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1160\/TH09-01-0029","volume":"102","author":"Lievens","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH11-07-0501-64","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.12.019"},{"key":"10.1160\/TH11-07-0501-65","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070159"},{"key":"10.1160\/TH11-07-0501-66","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261206"},{"key":"10.1160\/TH11-07-0501-67","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.03.051"},{"key":"10.1160\/TH11-07-0501-68","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1161\/01.CIR.103.13.1772","volume":"103","author":"von","year":"2001","journal-title":"Circulation"},{"key":"10.1160\/TH11-07-0501-69","doi-asserted-by":"publisher","DOI":"10.1038\/nm810"},{"key":"10.1160\/TH11-07-0501-70","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000253886.44609.ae"},{"key":"10.1160\/TH11-07-0501-71","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"10.1160\/TH11-07-0501-72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005743107"},{"key":"10.1160\/TH11-07-0501-73","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142883"},{"key":"10.1160\/TH11-07-0501-74","doi-asserted-by":"crossref","first-page":"6399","DOI":"10.4049\/jimmunol.174.10.6399","volume":"174","author":"Soehnlein","year":"2005","journal-title":"J Immunol"},{"key":"10.1160\/TH11-07-0501-75","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64907-3"},{"key":"10.1160\/TH11-07-0501-76","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.5.739"},{"key":"10.1160\/TH11-07-0501-77","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-139634"},{"key":"10.1160\/TH11-07-0501-78","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-221630"},{"key":"10.1160\/TH11-07-0501-79","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4049\/jimmunol.173.1.428","volume":"173","author":"Sun","year":"2004","journal-title":"J Immunol"},{"key":"10.1160\/TH11-07-0501-80","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1681\/ASN.V125932","volume":"12","author":"Taekema-Roelvink","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1160\/TH11-07-0501-81","doi-asserted-by":"crossref","first-page":"7341","DOI":"10.4049\/jimmunol.174.11.7341","volume":"174","author":"Berahovich","year":"2005","journal-title":"J Immunol"},{"key":"10.1160\/TH11-07-0501-82","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80334-9"},{"key":"10.1160\/TH11-07-0501-83","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00151-0"},{"key":"10.1160\/TH11-07-0501-84","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11871"},{"key":"10.1160\/TH11-07-0501-85","doi-asserted-by":"publisher","DOI":"10.2174\/138945007783220650"},{"key":"10.1160\/TH11-07-0501-86","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1161\/01.CIR.101.25.2883","volume":"101","author":"Liuzzo","year":"2000","journal-title":"Circulation"},{"key":"10.1160\/TH11-07-0501-87","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr007"},{"key":"10.1160\/TH11-07-0501-88","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-063826"},{"key":"10.1160\/TH11-07-0501-89","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1182\/blood.V89.11.4128","volume":"89","author":"Fanger","year":"1997","journal-title":"Blood"},{"key":"10.1160\/TH11-07-0501-90","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.034132"},{"key":"10.1160\/TH11-07-0501-91","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2008.02.008"},{"key":"10.1160\/TH11-07-0501-92","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.07.006"},{"key":"10.1160\/TH11-07-0501-93","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-010389"},{"key":"10.1160\/TH11-07-0501-94","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1182\/blood.V80.1.225.225","volume":"80","author":"Klebanoff","year":"1992","journal-title":"Blood"},{"key":"10.1160\/TH11-07-0501-95","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e32833dc7f9"},{"key":"10.1160\/TH11-07-0501-96","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-216085"},{"key":"10.1160\/TH11-07-0501-97","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2010.491123"},{"key":"10.1160\/TH11-07-0501-98","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4676"},{"key":"10.1160\/TH11-07-0501-99","doi-asserted-by":"publisher","DOI":"10.1038\/nri1996"},{"key":"10.1160\/TH11-07-0501-100","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.210781"},{"key":"10.1160\/TH11-07-0501-101","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082129"},{"key":"10.1160\/TH11-07-0501-102","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.94"},{"key":"10.1160\/TH11-07-0501-103","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28549"},{"key":"10.1160\/TH11-07-0501-104","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.4.503"},{"key":"10.1160\/TH11-07-0501-105","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi282"},{"key":"10.1160\/TH11-07-0501-106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03444.x"},{"key":"10.1160\/TH11-07-0501-107","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00447-9"},{"key":"10.1160\/TH11-07-0501-108","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0905526"},{"key":"10.1160\/TH11-07-0501-109","doi-asserted-by":"publisher","DOI":"10.1038\/nature06116"},{"key":"10.1160\/TH11-07-0501-110","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090480"},{"key":"10.1160\/TH11-07-0501-111","doi-asserted-by":"publisher","DOI":"10.1038\/ni1457"},{"key":"10.1160\/TH11-07-0501-112","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041310"},{"key":"10.1160\/TH11-07-0501-113","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4049\/jimmunol.175.1.487","volume":"175","author":"Wittamer","year":"2005","journal-title":"J Immunol"},{"key":"10.1160\/TH11-07-0501-114","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080129"},{"key":"10.1160\/TH11-07-0501-115","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.07.013"},{"key":"10.1160\/TH11-07-0501-116","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.5025"},{"key":"10.1160\/TH11-07-0501-117","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1189\/jlb.68.1.9","volume":"68","author":"Yang","year":"2000","journal-title":"J Leukocyte Biol"},{"key":"10.1160\/TH11-07-0501-118","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00472.2008"},{"key":"10.1160\/TH11-07-0501-119","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001180"},{"key":"10.1160\/TH11-07-0501-120","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001201"},{"key":"10.1160\/TH11-07-0501-121","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1959"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1160\/TH11-07-0501.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T16:19:21Z","timestamp":1686413961000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1160\/TH11-07-0501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":121,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,23]]},"published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1160\/th11-07-0501","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}