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Platelet GPVI not only mediates platelet activation at the site of vascular injury where collagen is exposed, but is also implicated in the pathogenesis of other diseases, such as atherosclerosis and coagulopathy, rheumatoid arthritis and tumour metastasis. Here, we describe some of the critical mechanisms for generating soluble GPVI from platelets, and future avenues for exploiting this unique platelet-specific receptor for diagnosis and\/or disease prevention.<\/jats:p>","DOI":"10.1160\/th11-10-0745","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T07:05:39Z","timestamp":1327475139000},"page":"648-655","source":"Crossref","is-referenced-by-count":42,"title":["Focusing on plasma glycoprotein VI"],"prefix":"10.1160","volume":"107","author":[{"given":"Jane F.","family":"Arthur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Gardiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Andrews","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Al-Tamimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"10.1160\/TH11-10-0745-1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-283838"},{"key":"10.1160\/TH11-10-0745-2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02590.x"},{"key":"10.1160\/TH11-10-0745-3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-086983"},{"key":"10.1160\/TH11-10-0745-4","doi-asserted-by":"publisher","DOI":"10.1080\/09537100802710286"},{"key":"10.1160\/TH11-10-0745-5","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.158527"},{"key":"10.1160\/TH11-10-0745-6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.07.017"},{"key":"10.1160\/TH11-10-0745-7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.980623"},{"key":"10.1160\/TH11-10-0745-8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.29019"},{"key":"10.1160\/TH11-10-0745-9","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1160\/TH04-09-0584","volume":"93","author":"Arthur","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1160\/TH11-10-0745-10","doi-asserted-by":"crossref","unstructured":"Andrews R, Berndt M, Lopez J. 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