{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:26:28Z","timestamp":1791588388914,"version":"4.3.4"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"Dutch Hemophilia Foundation (Stichting Hemophilia)"},{"name":"CSL Behring (unrestricted grant)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We performed a nation-wide cross-sectional study to evaluate determinants of bleeding symptoms in a large unselected cohort of adults with von Willebrand disease (VWD). VWD patients were included (n=664), based on lowest historically measured VWF:Ag and VWF:Act levels \u226430 U\/dl. Menorrhagia (85%), cutaneous bleeding (77%), bleeding from minor wounds (77%) and oral-cavity bleeding (62%) occurred most frequently. Higher age was associated with a higher bleeding score (BS), determined according to Tosetto, in females. A 10 year increase in age was associated with 0.8 point (95% confidence interval [CI] 0.4\u20131.1) higher BS. Females had higher BS than males (median 12 vs. 10, p=0.012). BS differed significantly between VWD type 1, 2 and 3: median 9 (-2\u201331), 13 (-1\u201333) and 19.5 (1\u201335), respectively (p&lt;0.001). BS was strongly associated with VWF and FVIII levels: individuals with VWF:Ag levels \u226410 IU\/dl, VWF:Act \u226410 IU\/dl and FVIII:C \u226410 IU\/dl had, respectively, 5.3 point (95%CI 3.2\u20137.3), 4.3 point (95%CI 2.9\u20135.8) and 9.6 point (95%CI 6.5\u201312.7) higher BS, than those with levels &gt;30 IU\/dl. In type 3 patients 1 IU\/dl FVIII:C decrease was associated with 0.6 point (95% CI 0.1\u20131.1) BS increase (p=0.021). In conclusion, in VWD patients the bleeding phenotype is strongly associated with type of VWD and VWF and FVIII levels.<\/jats:p>","DOI":"10.1160\/th12-04-0244","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T10:02:15Z","timestamp":1345802535000},"page":"683-692","source":"Crossref","is-referenced-by-count":113,"title":["Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease"],"prefix":"10.1160","volume":"108","author":[{"given":"Eva M.","family":"de Wee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne V.","family":"Sanders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline P.","family":"Mauser-Bunschoten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna G.","family":"van der Bom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon E. 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P.","family":"Laros-van Gorkom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Meijer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karly","family":"Hamuly\u00e1k","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marten R.","family":"Nijziel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Fijnvandraat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W. G.","family":"Leebeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the WiN study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"10.1160\/TH12-04-0244-1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V69.2.454.454","volume":"69","author":"Rodeghiero","year":"1987","journal-title":"Blood"},{"key":"10.1160\/TH12-04-0244-2","doi-asserted-by":"publisher","DOI":"10.1053\/beha.2001.0133"},{"key":"10.1160\/TH12-04-0244-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.03.012"},{"key":"10.1160\/TH12-04-0244-4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-949665"},{"key":"10.1160\/TH12-04-0244-5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01272.x"},{"key":"10.1160\/TH12-04-0244-6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02146.x"},{"key":"10.1160\/TH12-04-0244-7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01847.x"},{"key":"10.1160\/TH12-04-0244-8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03182.x"},{"key":"10.1160\/TH12-04-0244-9","doi-asserted-by":"crossref","unstructured":"Gill JC, et al. 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